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- CrcB_RNA_motif abstract "The crcB RNA motif (now called the fluoride riboswitch) is a conserved RNA structure identified by bioinformatics in a wide variety of bacteria and archaea. These RNAs were later shown to function as riboswitches that sense fluoride ions. These "fluoride riboswitches" increase expression of downstream genes when fluoride levels are elevated, and the genes are proposed to help mitigate the toxic effects of very high levels of fluoride.Many genes are presumed to be regulated by these fluoride riboswitches. Two of the most common encode proteins that are proposed to function by removing fluoride from the cell. These proteins are CrcB proteins and a fluoride-specific subtype of chloride channels referred to as EriC^F or ClC^F. ClC^F proteins have been shown to function as fluoride-specific fluoride/proton antiporters.The three-dimensional structure of a fluoride riboswitch has been solved at atomic resolution by X-ray crystallography.Fluoride riboswitches are found in many organisms within the domains bacteria and archaea, indicating that many of these organisms sometimes encounter elevated levels of fluoride. Of particular interest is Streptococcus mutans, a major cause of dental caries. It has been shown that sodium fluoride has inhibited the growth rate of S. mutans using glucose as an energy and carbon source. However, it is also noteworthy that many organisms that do not encounter fluoride in the human mouth carry fluoride riboswitches or resistance genes.".
- CrcB_RNA_motif thumbnail CrcB-RNA.svg?width=300.
- CrcB_RNA_motif wikiPageID "26608251".
- CrcB_RNA_motif wikiPageRevisionID "596998072".
- CrcB_RNA_motif caption "Consensus secondary structure of crcB RNAs".
- CrcB_RNA_motif hasPhotoCollection CrcB_RNA_motif.
- CrcB_RNA_motif name "crcB RNA motif".
- CrcB_RNA_motif rfam "RF01734".
- CrcB_RNA_motif rnaType Cis-regulatory_element.
- CrcB_RNA_motif rnaType Riboswitch.
- CrcB_RNA_motif symbol "crcB RNA".
- CrcB_RNA_motif taxDomain Prokaryote.
- CrcB_RNA_motif subject Category:Cis-regulatory_RNA_elements.
- CrcB_RNA_motif type Abstraction100002137.
- CrcB_RNA_motif type Cis-regulatoryRNAElements.
- CrcB_RNA_motif type Cognition100023271.
- CrcB_RNA_motif type Component105868954.
- CrcB_RNA_motif type Concept105835747.
- CrcB_RNA_motif type Content105809192.
- CrcB_RNA_motif type Idea105833840.
- CrcB_RNA_motif type Part105867413.
- CrcB_RNA_motif type PsychologicalFeature100023100.
- CrcB_RNA_motif comment "The crcB RNA motif (now called the fluoride riboswitch) is a conserved RNA structure identified by bioinformatics in a wide variety of bacteria and archaea. These RNAs were later shown to function as riboswitches that sense fluoride ions.".
- CrcB_RNA_motif label "CrcB RNA motif".
- CrcB_RNA_motif sameAs m.0bhbf47.
- CrcB_RNA_motif sameAs Q5183303.
- CrcB_RNA_motif sameAs Q5183303.
- CrcB_RNA_motif sameAs CrcB_RNA_motif.
- CrcB_RNA_motif wasDerivedFrom CrcB_RNA_motif?oldid=596998072.
- CrcB_RNA_motif depiction CrcB-RNA.svg.
- CrcB_RNA_motif isPrimaryTopicOf CrcB_RNA_motif.