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- Cullin abstract "Cullins are a family of hydrophobic proteins providing a scaffold for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in a myriad of cellular processes. Human genome contains seven cullin genes: CUL1, part of SCF complex CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 a more distant member called ANAPC2, part of Anaphase-promoting complexCUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins.With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae (Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.".
- Cullin symbol "Cullin".
- Cullin symbol "Cullin_Nedd8".
- Cullin thumbnail PDB_1ldk_EBI.jpg?width=300.
- Cullin wikiPageExternalLink family?id=Cullin.
- Cullin wikiPageID "19209638".
- Cullin wikiPageRevisionID "593889053".
- Cullin caption "structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex".
- Cullin hasPhotoCollection Cullin.
- Cullin interpro "IPR001373".
- Cullin interpro "IPR019559".
- Cullin name "Cullin protein neddylation domain".
- Cullin name "Cullin".
- Cullin pfam "PF00888".
- Cullin pfam "PF10557".
- Cullin prosite "PDOC00967".
- Cullin scop "1".
- Cullin symbol "Cullin".
- Cullin symbol "Cullin_Nedd8".
- Cullin subject Category:Protein_families.
- Cullin subject Category:Proteins.
- Cullin type Abstraction100002137.
- Cullin type Family108078020.
- Cullin type Group100031264.
- Cullin type Organization108008335.
- Cullin type ProteinFamilies.
- Cullin type SocialGroup107950920.
- Cullin type Unit108189659.
- Cullin type YagoLegalActor.
- Cullin type YagoLegalActorGeo.
- Cullin type YagoPermanentlyLocatedEntity.
- Cullin type Biomolecule.
- Cullin type Protein.
- Cullin type BiologicalObject.
- Cullin comment "Cullins are a family of hydrophobic proteins providing a scaffold for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in a myriad of cellular processes.".
- Cullin label "Cullin".
- Cullin sameAs m.05h3ldr.
- Cullin sameAs Q5193031.
- Cullin sameAs Q5193031.
- Cullin sameAs Cullin.
- Cullin wasDerivedFrom Cullin?oldid=593889053.
- Cullin depiction PDB_1ldk_EBI.jpg.
- Cullin isPrimaryTopicOf Cullin.