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- Cyclin_T1 abstract "Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.".
- Cyclin_T1 entrezgene "904".
- Cyclin_T1 wikiPageID "14026571".
- Cyclin_T1 wikiPageRevisionID "594701018".
- Cyclin_T1 hasPhotoCollection Cyclin_T1.
- Cyclin_T1 requireManualInspection "no".
- Cyclin_T1 summaryText "The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain of the largest RNA polymerase II subunit.".
- Cyclin_T1 updateCitations "yes".
- Cyclin_T1 updatePage "yes".
- Cyclin_T1 updateProteinBox "yes".
- Cyclin_T1 updateSummary "yes".
- Cyclin_T1 type Biomolecule.
- Cyclin_T1 type Protein.
- Cyclin_T1 type BiologicalObject.
- Cyclin_T1 comment "Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of each mitotic event.".
- Cyclin_T1 label "Cyclin T1".
- Cyclin_T1 sameAs m.03crfb3.
- Cyclin_T1 sameAs Q5198279.
- Cyclin_T1 sameAs Q5198279.
- Cyclin_T1 wasDerivedFrom Cyclin_T1?oldid=594701018.
- Cyclin_T1 isPrimaryTopicOf Cyclin_T1.