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- Cycloheximide abstract "Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome) thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e. outside of organisms). It is inexpensive and works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium.Due to significant toxic side effects, including DNA damage, teratogenesis, and other reproductive effects (including birth defects and toxicity to sperm), cycloheximide is generally used only in in vitro research applications, and is not suitable for human use as a therapeutic compound. Although it has been used as a fungicide in agricultural applications, this application is now decreasing as the health risks have become better understood.Cycloheximide is degraded by alkali (pH > 7), decontamination of work surfaces and containers can be achieved by washing with a non-harmful alkali solution such as soap.Since cycloheximide is an effective inhibitor of protein biosynthesis in eukaryotes only, it may be used to distinguish between proteins translated in the mitochondria and proteins translated in the cytosol. mRNA translated in cytosol or ER from mRNA derived from the nucleus will not be expressed in the presence of cycloheximide. Conversely, translation using mitochondrial ribosomes is unaffected by cycloheximide, and mitochondrial genes will continue to be expressed.".
- Cycloheximide iupacName "4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione".
- Cycloheximide thumbnail Cycloheximide.png?width=300.
- Cycloheximide wikiPageExternalLink cycloheximide.html.
- Cycloheximide wikiPageID "2109062".
- Cycloheximide wikiPageRevisionID "594874181".
- Cycloheximide hasPhotoCollection Cycloheximide.
- Cycloheximide imagefile "Cycloheximide.png".
- Cycloheximide imagename "Cycloheximide".
- Cycloheximide iupacname "4".
- Cycloheximide name "Cycloheximide".
- Cycloheximide othernames "actidione, actispray".
- Cycloheximide othernames "kaken, U-4527".
- Cycloheximide othernames "naramycin a, hizarocin".
- Cycloheximide verifiedfields "changed".
- Cycloheximide verifiedrevid "460110426".
- Cycloheximide subject Category:Alcohols.
- Cycloheximide subject Category:Antibiotics.
- Cycloheximide subject Category:Fungicides.
- Cycloheximide subject Category:Glutarimides.
- Cycloheximide subject Category:Ketones.
- Cycloheximide type Abstraction100002137.
- Cycloheximide type Agent114778436.
- Cycloheximide type Alcohol107884567.
- Cycloheximide type Alcohols.
- Cycloheximide type Beverage107881800.
- Cycloheximide type CausalAgent100007347.
- Cycloheximide type Chemical114806838.
- Cycloheximide type Compound114818238.
- Cycloheximide type Drug103247620.
- Cycloheximide type DrugOfAbuse103248958.
- Cycloheximide type Fluid114939900.
- Cycloheximide type Food100021265.
- Cycloheximide type Ketone114926294.
- Cycloheximide type Ketones.
- Cycloheximide type Liquid114940386.
- Cycloheximide type Material114580897.
- Cycloheximide type Matter100020827.
- Cycloheximide type OrganicCompound114727670.
- Cycloheximide type Part113809207.
- Cycloheximide type PhysicalEntity100001930.
- Cycloheximide type Relation100031921.
- Cycloheximide type Substance100019613.
- Cycloheximide type Substance100020090.
- Cycloheximide type ChemicalCompound.
- Cycloheximide type ChemicalSubstance.
- Cycloheximide type ChemicalSubstanceType.
- Cycloheximide type ChemicalObject.
- Cycloheximide type Thing.
- Cycloheximide comment "Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome) thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e. outside of organisms).".
- Cycloheximide label "Cicloesimide".
- Cycloheximide label "Cicloheximida".
- Cycloheximide label "Cycloheximid".
- Cycloheximide label "Cycloheximide".
- Cycloheximide label "Cycloheximide".
- Cycloheximide label "Cycloheximide".
- Cycloheximide label "Cykloheksymid".
- Cycloheximide label "シクロヘキシミド".
- Cycloheximide label "放线菌酮".
- Cycloheximide sameAs Cykloheximid.
- Cycloheximide sameAs Cycloheximid.
- Cycloheximide sameAs Cicloheximida.
- Cycloheximide sameAs Cycloheximide.
- Cycloheximide sameAs Cicloesimide.
- Cycloheximide sameAs シクロヘキシミド.
- Cycloheximide sameAs Cycloheximide.
- Cycloheximide sameAs Cykloheksymid.
- Cycloheximide sameAs m.06mq8v.
- Cycloheximide sameAs Q412895.
- Cycloheximide sameAs Q412895.
- Cycloheximide sameAs Cycloheximide.
- Cycloheximide wasDerivedFrom Cycloheximide?oldid=594874181.
- Cycloheximide depiction Cycloheximide.png.
- Cycloheximide isPrimaryTopicOf Cycloheximide.
- Cycloheximide name "Cycloheximide".