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- Cyclol abstract "The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such "closed cyclol" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.".
- Cyclol thumbnail Cyclol_reaction.png?width=300.
- Cyclol wikiPageID "6884590".
- Cyclol wikiPageRevisionID "592382885".
- Cyclol hasPhotoCollection Cyclol.
- Cyclol subject Category:History_of_chemistry.
- Cyclol subject Category:Obsolete_scientific_theories.
- Cyclol subject Category:Protein_structure.
- Cyclol type Abstraction100002137.
- Cyclol type Cognition100023271.
- Cyclol type Explanation105793000.
- Cyclol type HigherCognitiveProcess105770664.
- Cyclol type ObsoleteScientificTheories.
- Cyclol type Process105701363.
- Cyclol type PsychologicalFeature100023100.
- Cyclol type ScientificTheory105993844.
- Cyclol type Theory105989479.
- Cyclol type Thinking105770926.
- Cyclol comment "The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds.".
- Cyclol label "Cyclol".
- Cyclol label "Cyclol".
- Cyclol label "Hipótesis del ciclol".
- Cyclol label "Циклолы".
- Cyclol label "环醇假说".
- Cyclol sameAs Hipótesis_del_ciclol.
- Cyclol sameAs Cyclol.
- Cyclol sameAs m.0gv6n5.
- Cyclol sameAs Q2443652.
- Cyclol sameAs Q2443652.
- Cyclol sameAs Cyclol.
- Cyclol wasDerivedFrom Cyclol?oldid=592382885.
- Cyclol depiction Cyclol_reaction.png.
- Cyclol isPrimaryTopicOf Cyclol.