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- Cyclopamine abstract "Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed. Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho. In 1957 the US Department of Agriculture started an eleven-year investigation which led to the identification of cyclopamine as the cause of the birth defect.".
- Cyclopamine iupacName "(3β,23R)-17,23-Epoxyveratraman-3-ol".
- Cyclopamine thumbnail Cyclopamine2DACS.svg?width=300.
- Cyclopamine wikiPageExternalLink 070830155859.htm.
- Cyclopamine wikiPageExternalLink 0,71569-0.html.
- Cyclopamine wikiPageID "3948000".
- Cyclopamine wikiPageRevisionID "602818634".
- Cyclopamine hasPhotoCollection Cyclopamine.
- Cyclopamine imagefile "Cyclopamine2DACS.svg".
- Cyclopamine imagesize "200".
- Cyclopamine iupacname "-1723".
- Cyclopamine othernames "• -1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7'a,8,11,11a,11b-octadecahydro-3′,6′,10,11b-tetramethyl-spiro[9H-benzo[a]fluorene-9,2′-furo[3,2-b]pyridin]-3-ol".
- Cyclopamine othernames "• 11-Deoxojervine".
- Cyclopamine verifiedrevid "443547922".
- Cyclopamine subject Category:Alcohols.
- Cyclopamine subject Category:Jervines.
- Cyclopamine subject Category:Spiro_compounds.
- Cyclopamine subject Category:Teratogens.
- Cyclopamine type Abstraction100002137.
- Cyclopamine type Agent114778436.
- Cyclopamine type Alcohol107884567.
- Cyclopamine type Alcohols.
- Cyclopamine type Beverage107881800.
- Cyclopamine type CausalAgent100007347.
- Cyclopamine type Cognition100023271.
- Cyclopamine type Compound105870180.
- Cyclopamine type Concept105835747.
- Cyclopamine type Content105809192.
- Cyclopamine type Drug103247620.
- Cyclopamine type DrugOfAbuse103248958.
- Cyclopamine type Fluid114939900.
- Cyclopamine type Food100021265.
- Cyclopamine type Idea105833840.
- Cyclopamine type Liquid114940386.
- Cyclopamine type Matter100020827.
- Cyclopamine type Part113809207.
- Cyclopamine type PhysicalEntity100001930.
- Cyclopamine type PsychologicalFeature100023100.
- Cyclopamine type Relation100031921.
- Cyclopamine type SpiroCompounds.
- Cyclopamine type Substance100019613.
- Cyclopamine type Substance100020090.
- Cyclopamine type Whole105869584.
- Cyclopamine type ChemicalCompound.
- Cyclopamine type ChemicalSubstance.
- Cyclopamine type ChemicalSubstanceType.
- Cyclopamine type ChemicalObject.
- Cyclopamine type Thing.
- Cyclopamine comment "Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh).".
- Cyclopamine label "Ciclopamina".
- Cyclopamine label "Cyclopamine".
- Cyclopamine label "Cyclopamine".
- Cyclopamine label "シクロパミン".
- Cyclopamine label "环杷明".
- Cyclopamine sameAs Ciclopamina.
- Cyclopamine sameAs Cyclopamine.
- Cyclopamine sameAs シクロパミン.
- Cyclopamine sameAs m.0b844d.
- Cyclopamine sameAs Q3271319.
- Cyclopamine sameAs Q3271319.
- Cyclopamine sameAs Cyclopamine.
- Cyclopamine wasDerivedFrom Cyclopamine?oldid=602818634.
- Cyclopamine depiction Cyclopamine2DACS.svg.
- Cyclopamine isPrimaryTopicOf Cyclopamine.