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- Cymserine abstract "Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity (15x) for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of the more well known acetylcholinesterase enzyme. This gives it a much more specific profile of effects that may be useful for treating Alzheimer's disease without producing side effects like tremor, lacrimation and salivation that are seen with the older non-selective cholinesterase inhibitors currently used for this application, such as donepezil. A number of cymserine derivatives have been developed with much greater selectivity for butyrylcholinesterase, and both cymserine itself and several of its analogues have been tested in animals, and found to increase brain acetylcholine levels and produce nootropic effects, as well as reducing levels of amyloid precursor protein and amyloid beta, which are commonly used biomarkers for the development of Alzheimer's disease.".
- Cymserine casNumber "145209-39-8".
- Cymserine iupacName "((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl)-4-isopropylphenylcarbamate".
- Cymserine pubchem "9907847".
- Cymserine thumbnail Cymserine_structure.png?width=300.
- Cymserine wikiPageID "31770614".
- Cymserine wikiPageRevisionID "603065752".
- Cymserine c "23".
- Cymserine casNumber "145209".
- Cymserine chemspiderid "26000641".
- Cymserine h "29".
- Cymserine hasPhotoCollection Cymserine.
- Cymserine iupacName "-4".
- Cymserine molecularWeight "379.495".
- Cymserine n "3".
- Cymserine o "2".
- Cymserine pubchem "9907847".
- Cymserine smiles "C[C@@]12[C@@]NC3=CC=CC=C31".
- Cymserine stdinchi "1".
- Cymserine stdinchikey "WHFRVERUBMJQSO-GHTZIAJQSA-N".
- Cymserine verifiedrevid "430522824".
- Cymserine width "220".
- Cymserine subject Category:Alkaloids.
- Cymserine subject Category:Carbamates.
- Cymserine subject Category:Indole_alkaloids.
- Cymserine subject Category:Pyrroloindoles.
- Cymserine subject Category:Butyrylcholinesterase_inhibitors.
- Cymserine type Abstraction100002137.
- Cymserine type Alkaloid114712692.
- Cymserine type Alkaloids.
- Cymserine type Carbamate114792281.
- Cymserine type Carbamates.
- Cymserine type Chemical114806838.
- Cymserine type Compound114818238.
- Cymserine type Material114580897.
- Cymserine type Matter100020827.
- Cymserine type OrganicCompound114727670.
- Cymserine type Part113809207.
- Cymserine type PhysicalEntity100001930.
- Cymserine type Relation100031921.
- Cymserine type Salt115010703.
- Cymserine type Substance100019613.
- Cymserine type Drug.
- Cymserine type FunctionalSubstance.
- Cymserine comment "Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity (15x) for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of the more well known acetylcholinesterase enzyme.".
- Cymserine label "Cymserine".
- Cymserine sameAs m.0gttb5t.
- Cymserine sameAs Q5199864.
- Cymserine sameAs Q5199864.
- Cymserine sameAs Cymserine.
- Cymserine wasDerivedFrom Cymserine?oldid=603065752.
- Cymserine depiction Cymserine_structure.png.
- Cymserine isPrimaryTopicOf Cymserine.