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- Cystinosis abstract "Cystinosis is a lysosomal storage disease characterized by the abnormal accumulation of the amino acid cystine. It is a genetic disorder that typically follows an autosomal recessive inheritance pattern. Cystinosis is the most common cause of Fanconi syndrome in the pediatric age group. Fanconi syndrome occurs when the function of cells in renal tubules are impaired, leading to abnormal amounts of carbohydrates and amino acids in the urine, excessive urination, and low blood levels of potassium and phosphates.Cystinosis was the first documented genetic disease belonging to the group of lysosomal-transport-defect disorders. It is a rare autosomal recessive disorder resulting from accumulation of free cystine in lysosomes, eventually leading to intracellular crystal formation throughout the body. Cystinosis is caused by mutations in the CTNS gene that codes for cystinosin, the lysosomal membrane-specific transporter for cystine. Intracellular metabolism of cystine, as it happens with all amino acids, requires its transport across the cell membrane. After degradation of endocytosed protein to cystine within lysosomes, it is normally transported to the cytosol. But if there is a defect in the carrier protein, cystine is accumulated in lysosomes. As cystine is highly insoluble, when its concentration in tissue lysosomes increase, its solubility is immediately exceeded and crystalline precipitates are formed in almost all organs and tissues.However, the progression of the disease is not related to the presence of crystals in target tissues. Although tissue damage might depend on cystine accumulation, the mechanisms of tissue damage are not fully understood. Increased intracellular cystine profoundly disturbs cellular oxidative metabolism and glutathione status, leading to altered mitochondrial energy metabolism, autophagy, and apoptosis.Cystinosis is usually treated with cysteamine, which is prescribed to decrease intralysosomal cystine accumulation. However, the recent discovery of new pathogenic mechanisms and the development of an animal model of the disease may open possibilities for the development of new treatment modalities to improve long-term prognosis.".
- Cystinosis diseasesdb "3382".
- Cystinosis emedicineSubject "ped".
- Cystinosis emedicineTopic "538".
- Cystinosis icd10 "E72.0".
- Cystinosis icd9 "270.0".
- Cystinosis meshId "D003554".
- Cystinosis thumbnail Cystine-skeletal.png?width=300.
- Cystinosis wikiPageExternalLink knowcystinosis.com.
- Cystinosis wikiPageExternalLink nord59.htm.
- Cystinosis wikiPageExternalLink www.cystinosis.ie.
- Cystinosis wikiPageExternalLink www.cystinosis.org.
- Cystinosis wikiPageExternalLink www.cystinosis.org.uk.
- Cystinosis wikiPageExternalLink www.cystinosisfoundation.org.
- Cystinosis wikiPageExternalLink www.cystinosisregistry.org.
- Cystinosis wikiPageExternalLink www.cystinosisresearch.org.
- Cystinosis wikiPageExternalLink www.hideandseek.org.
- Cystinosis wikiPageExternalLink br.fcgi?book=gene&part=ctns.
- Cystinosis wikiPageID "1899336".
- Cystinosis wikiPageRevisionID "604134823".
- Cystinosis caption "Chemical structure of cystine formed from L-cysteine".
- Cystinosis diseasesdb "3382".
- Cystinosis emedicinesubj "ped".
- Cystinosis emedicinetopic "538".
- Cystinosis hasPhotoCollection Cystinosis.
- Cystinosis icd "270".
- Cystinosis icd "E72.0".
- Cystinosis meshid "D003554".
- Cystinosis name "Cystinosis".
- Cystinosis wordnet_type synset-disease-noun-1.
- Cystinosis subject Category:Amino_acid_metabolism_disorders.
- Cystinosis subject Category:Autosomal_recessive_disorders.
- Cystinosis subject Category:Lysosomal_storage_diseases.
- Cystinosis type Abstraction100002137.
- Cystinosis type AminoAcidMetabolismDisorders.
- Cystinosis type Attribute100024264.
- Cystinosis type AutosomalRecessiveDisorders.
- Cystinosis type Condition113920835.
- Cystinosis type Disease114070360.
- Cystinosis type Disorder114052403.
- Cystinosis type IllHealth114052046.
- Cystinosis type Illness114061805.
- Cystinosis type PathologicalState114051917.
- Cystinosis type PhysicalCondition114034177.
- Cystinosis type State100024720.
- Cystinosis type Disease.
- Cystinosis type AilmentCondition.
- Cystinosis type Situation.
- Cystinosis comment "Cystinosis is a lysosomal storage disease characterized by the abnormal accumulation of the amino acid cystine. It is a genetic disorder that typically follows an autosomal recessive inheritance pattern. Cystinosis is the most common cause of Fanconi syndrome in the pediatric age group.".
- Cystinosis label "Cistinosi".
- Cystinosis label "Cistinosis".
- Cystinosis label "Cystinose".
- Cystinosis label "Cystinose".
- Cystinosis label "Cystinose".
- Cystinosis label "Cystinosis".
- Cystinosis label "Cystynoza".
- Cystinosis label "Цистиноз".
- Cystinosis label "胱胺酸症".
- Cystinosis sameAs Cystinose.
- Cystinosis sameAs Cistinosis.
- Cystinosis sameAs Cystinose.
- Cystinosis sameAs Sistinosis.
- Cystinosis sameAs Cistinosi.
- Cystinosis sameAs Cystinose.
- Cystinosis sameAs Cystynoza.
- Cystinosis sameAs m.064rf4.
- Cystinosis sameAs Q1149042.
- Cystinosis sameAs Q1149042.
- Cystinosis sameAs 298.
- Cystinosis sameAs Cystinosis.
- Cystinosis wasDerivedFrom Cystinosis?oldid=604134823.
- Cystinosis depiction Cystine-skeletal.png.
- Cystinosis isPrimaryTopicOf Cystinosis.
- Cystinosis name "Cystinosis".