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- DNA_mismatch_repair abstract "DNA mismatch repair is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.Mismatch repair is strand-specific. During DNA synthesis the newly synthesised (daughter) strand will commonly include errors. In order to begin repair, the mismatch repair machinery distinguishes the newly synthesised strand from the template (parental). In gram-negative bacteria, transient hemimethylation distinguishes the strands (the parental is methylated and daughter is not). However, in other prokaryotes and eukaryotes, the exact mechanism is not clear. It is suspected that, in eukaryotes, newly synthesized lagging-strand DNA transiently contains nicks (before being sealed by DNA ligase) and provides a signal that directs mismatch proofreading systems to the appropriate strand. This implies that these nicks must be present in the leading strand, and evidence for this has recently been found.Recent work has shown that nicks are sites for RFC-dependent loading of the replication sliding clamp PCNA, in an orientation-specific manner, such that one face of the donut-shape protein is juxtaposed toward the 3'-OH end at the nick. Oriented PCNA then directs the action of the MutLalpha endonuclease to one strand in the presence of a mismatch and MutSalpha or MutSbeta.Any mutational event that disrupts the superhelical structure of DNA carries with it the potential to compromise the genetic stability of a cell. The fact that the damage detection and repair systems are as complex as the replication machinery itself highlights the importance evolution has attached to DNA fidelity.Examples of mismatched bases include a G/T or A/C pairing (see DNA repair). Mismatches are commonly due to tautomerization of bases during G2. If this is based on WC tautomers, it should be noted that WC tautomers have not been seen in crystal structures.[citation needed]. The damage is repaired by recognition of the deformity caused by the mismatch, determining the template and non-template strand, and excising the wrongly incorporated base and replacing it with the correct nucleotide. The removal process involves more than just the mismatched nucleotide itself. A few or up to thousands of base pairs of the newly synthesized DNA strand can be removed.".
- DNA_mismatch_repair symbol "DNA_mis_repair".
- DNA_mismatch_repair thumbnail DNA_mismatch_repair.png?width=300.
- DNA_mismatch_repair wikiPageExternalLink DNArepair.html.
- DNA_mismatch_repair wikiPageID "2488614".
- DNA_mismatch_repair wikiPageRevisionID "606313479".
- DNA_mismatch_repair caption "hpms2-atpgs".
- DNA_mismatch_repair hasPhotoCollection DNA_mismatch_repair.
- DNA_mismatch_repair interpro "IPR013507".
- DNA_mismatch_repair name "DNA mismatch repair protein, C-terminal domain".
- DNA_mismatch_repair pfam "PF01119".
- DNA_mismatch_repair pfamClan "CL0329".
- DNA_mismatch_repair prosite "PDOC00057".
- DNA_mismatch_repair scop "1".
- DNA_mismatch_repair symbol "DNA_mis_repair".
- DNA_mismatch_repair subject Category:DNA_repair.
- DNA_mismatch_repair type Biomolecule.
- DNA_mismatch_repair type Protein.
- DNA_mismatch_repair type BiologicalObject.
- DNA_mismatch_repair comment "DNA mismatch repair is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.Mismatch repair is strand-specific. During DNA synthesis the newly synthesised (daughter) strand will commonly include errors. In order to begin repair, the mismatch repair machinery distinguishes the newly synthesised strand from the template (parental).".
- DNA_mismatch_repair label "DNA mismatch repair".
- DNA_mismatch_repair label "DNAミスマッチ修復".
- DNA_mismatch_repair label "Mismatch repair".
- DNA_mismatch_repair label "Репарация ошибочно спаренных нуклеотидов".
- DNA_mismatch_repair sameAs Mismatch_repair.
- DNA_mismatch_repair sameAs DNAミスマッチ修復.
- DNA_mismatch_repair sameAs m.07hfkq.
- DNA_mismatch_repair sameAs Q2984243.
- DNA_mismatch_repair sameAs Q2984243.
- DNA_mismatch_repair wasDerivedFrom DNA_mismatch_repair?oldid=606313479.
- DNA_mismatch_repair depiction DNA_mismatch_repair.png.
- DNA_mismatch_repair isPrimaryTopicOf DNA_mismatch_repair.