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- Darunavir abstract "Darunavir (brand name Prezista, formerly known as TMC114) is a protease inhibitor drug used to treat HIV infection. Prezista is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents. Developed by pharmaceutical company Tibotec, darunavir is named after Arun K. Ghosh, the chemist who discovered the molecule at the University of Illinois at Chicago. It was approved by the Food and Drug Administration (FDA) on June 23, 2006.Darunavir is a second-generation protease inhibitor (PIs), designed specifically to overcome problems with the older agents in this class, such as indinavir. Early PIs often have severe side effects and drug toxicities, require a high therapeutic dose, are costly to manufacture, and show a disturbing susceptibility to drug resistant mutations. Such mutations can develop in as little as a year of use, and effectively render the drugs useless.Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.Darunavir received much attention at the time of its release, as it represents an important treatment option for patients with drug-resistant HIV. Patient advocacy groups pressured developer Tibotec not to follow the previous trend of releasing new drugs at prices higher than existing drugs in the same class. Darunavir was priced to match other common PIs already in use, such as the fixed-dose combination drug lopinavir/ritonavir.".
- Darunavir atcPrefix "J05".
- Darunavir atcSuffix "AE10".
- Darunavir bioavailability "37.0".
- Darunavir casNumber "206361-99-1".
- Darunavir chEBI "367163".
- Darunavir drugbank "DB01264".
- Darunavir fdaUniiCode "YO603Y8113".
- Darunavir iupacName "[(1R,5S,6R)-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[(2S,3R)-4- [(4-aminophenyl)sulfonyl- (2-methylpropyl)amino]-3-hydroxy-1-phenyl- butan-2-yl] carbamate".
- Darunavir pubchem "213039".
- Darunavir thumbnail Darunavir2DCSD.svg?width=300.
- Darunavir wikiPageExternalLink download.cfm?articleid=352436&attachmentid=51602.
- Darunavir wikiPageExternalLink Darunavir.htm.
- Darunavir wikiPageExternalLink ghosh.
- Darunavir wikiPageExternalLink faculty.asp?itemID=76.
- Darunavir wikiPageExternalLink Darunavir_E.pdf.
- Darunavir wikiPageExternalLink 20060623_191250.htm;jsessionid=NT1BC4RC4RHKYCQPCAOWU3YKB2IIWTT.
- Darunavir wikiPageExternalLink www.tibotec.com.
- Darunavir wikiPageExternalLink bgdisplay.jhtml?itemname=HIV_tmc114.
- Darunavir wikiPageID "5702974".
- Darunavir wikiPageRevisionID "606805644".
- Darunavir atcPrefix "J05".
- Darunavir atcSuffix "AE10".
- Darunavir bioavailability "37".
- Darunavir c "27".
- Darunavir casNumber "206361".
- Darunavir chebi "367163".
- Darunavir chembl "1323".
- Darunavir chemspiderid "184733".
- Darunavir drugbank "DB01264".
- Darunavir eliminationHalfLife "54000.0".
- Darunavir excretion "Faeces , urine".
- Darunavir h "37".
- Darunavir hasPhotoCollection Darunavir.
- Darunavir image "Darunavir ball-and-stick animation.gif".
- Darunavir inchi "1".
- Darunavir inchikey "CJBJHOAVZSMMDJ-HEXNFIEUBK".
- Darunavir iupacName "[-2,8-dioxabicyclo[3.3.0]oct-6-yl] N-[-4- [sulfonyl- amino]-3-hydroxy-1-phenyl- butan-2-yl] carbamate".
- Darunavir kegg "D03656".
- Darunavir legalAu "S4".
- Darunavir legalCa "Rx-only".
- Darunavir legalUk "POM".
- Darunavir legalUs "Rx-only".
- Darunavir medlineplus "a607042".
- Darunavir metabolism "hepatic".
- Darunavir molecularWeight "547.665".
- Darunavir n "3".
- Darunavir niaidChemdb "73035".
- Darunavir o "7".
- Darunavir pregnancyAu "B2".
- Darunavir pregnancyUs "C".
- Darunavir proteinBound "95.0".
- Darunavir pubchem "213039".
- Darunavir routesOfAdministration "oral".
- Darunavir s "1".
- Darunavir smiles "O=SNC[C@@H][C@@H]Cc4ccccc4".
- Darunavir stdinchi "1".
- Darunavir stdinchikey "CJBJHOAVZSMMDJ-HEXNFIEUSA-N".
- Darunavir tradename "Prezista".
- Darunavir unii "YO603Y8113".
- Darunavir verifiedfields "changed".
- Darunavir verifiedrevid "460773860".
- Darunavir width "250".
- Darunavir subject Category:Belgian_inventions.
- Darunavir subject Category:Carbamates.
- Darunavir subject Category:Protease_inhibitors.
- Darunavir subject Category:Sulfonamides.
- Darunavir type Agent114778436.
- Darunavir type Antibacterial102716205.
- Darunavir type Antiviral102725367.
- Darunavir type CausalAgent100007347.
- Darunavir type Drug103247620.
- Darunavir type Matter100020827.
- Darunavir type Medicine103740161.
- Darunavir type PhysicalEntity100001930.
- Darunavir type ProteaseInhibitor104013993.
- Darunavir type ProteaseInhibitors.
- Darunavir type Substance100020090.
- Darunavir type SulfaDrug104352070.
- Darunavir type Sulfonamides.
- Darunavir type Drug.
- Darunavir type DrugProduct.
- Darunavir type FunctionalSubstance.
- Darunavir comment "Darunavir (brand name Prezista, formerly known as TMC114) is a protease inhibitor drug used to treat HIV infection. Prezista is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents. Developed by pharmaceutical company Tibotec, darunavir is named after Arun K. Ghosh, the chemist who discovered the molecule at the University of Illinois at Chicago.".
- Darunavir label "Darunavir".
- Darunavir label "Darunavir".
- Darunavir label "Darunavir".
- Darunavir sameAs Darunavir.
- Darunavir sameAs Darunavir.
- Darunavir sameAs m.0d__jn.
- Darunavir sameAs Q3765251.
- Darunavir sameAs Q3765251.
- Darunavir sameAs darunavir.
- Darunavir sameAs DB01264.
- Darunavir sameAs 213039.
- Darunavir sameAs Darunavir.
- Darunavir wasDerivedFrom Darunavir?oldid=606805644.
- Darunavir depiction Darunavir2DCSD.svg.
- Darunavir isPrimaryTopicOf Darunavir.