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- Denosumab abstract "Denosumab is a fully human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone. It was developed by the biotechnology company Amgen.Denosumab is designed to inhibit RANKL (RANK ligand), a protein that acts as the primary signal for bone removal. In many bone loss conditions, RANKL overwhelms the body's natural defenses against bone destruction.In June 2010, denosumab was approved by the U.S. Food and Drug Administration (FDA) for use in postmenopausal women with risk of osteoporosis under the trade name Prolia, and in November 2010, as Xgeva, for the prevention of skeleton-related events in patients with bone metastases from solid tumors. Denosumab is the first RANKL inhibitor to be approved by the FDA. In the summer of 2011 clinical trials were investigating denosumab in giant cell tumors, multiple myeloma with bone metastases, and hypercalcemia of malignancy, and further investigating its dosing and safety.".
- Denosumab atcPrefix "M05".
- Denosumab atcSuffix "BX04".
- Denosumab casNumber "615258-40-7".
- Denosumab fdaUniiCode "4EQZ6YO2HI".
- Denosumab wikiPageExternalLink prolia_pi.pdf.
- Denosumab wikiPageExternalLink xgeva_pi.pdf.
- Denosumab wikiPageExternalLink 31039.
- Denosumab wikiPageID "9033769".
- Denosumab wikiPageRevisionID "601063328".
- Denosumab atcPrefix "M05".
- Denosumab atcSuffix "BX04".
- Denosumab bioavailability "N/A".
- Denosumab c "6404".
- Denosumab casNumber "615258".
- Denosumab chembl "1237023".
- Denosumab chemspiderid "NA".
- Denosumab h "9912".
- Denosumab hasPhotoCollection Denosumab.
- Denosumab kegg "D03684".
- Denosumab legalUs "Rx-only".
- Denosumab licenceUs "Denosumab".
- Denosumab mabType "mab".
- Denosumab medlineplus "a610023".
- Denosumab metabolism Proteolysis.
- Denosumab molecularWeight "144.7".
- Denosumab n "1724".
- Denosumab o "2004".
- Denosumab pregnancyUs "C".
- Denosumab routesOfAdministration "subcutaneous injection, every six months".
- Denosumab s "50".
- Denosumab source "u".
- Denosumab synonyms "AMG 162".
- Denosumab target RANKL.
- Denosumab tradename "Prolia, Xgeva".
- Denosumab type "mab".
- Denosumab unii "4".
- Denosumab verifiedfields "changed".
- Denosumab verifiedrevid "460765534".
- Denosumab subject Category:Amgen.
- Denosumab subject Category:Monoclonal_antibodies.
- Denosumab type Abstraction100002137.
- Denosumab type Antibody115027189.
- Denosumab type Chemical114806838.
- Denosumab type Compound114818238.
- Denosumab type Macromolecule114944888.
- Denosumab type Material114580897.
- Denosumab type Matter100020827.
- Denosumab type Molecule114682133.
- Denosumab type MonoclonalAntibodies.
- Denosumab type MonoclonalAntibody115029781.
- Denosumab type OrganicCompound114727670.
- Denosumab type Part113809207.
- Denosumab type PhysicalEntity100001930.
- Denosumab type Protein114728724.
- Denosumab type Relation100031921.
- Denosumab type Substance100019613.
- Denosumab type Thing100002452.
- Denosumab type Unit109465459.
- Denosumab type Drug.
- Denosumab type DrugProduct.
- Denosumab type FunctionalSubstance.
- Denosumab comment "Denosumab is a fully human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone. It was developed by the biotechnology company Amgen.Denosumab is designed to inhibit RANKL (RANK ligand), a protein that acts as the primary signal for bone removal. In many bone loss conditions, RANKL overwhelms the body's natural defenses against bone destruction.In June 2010, denosumab was approved by the U.S.".
- Denosumab label "Denosumab".
- Denosumab label "Denosumab".
- Denosumab label "Denosumab".
- Denosumab label "Denosumab".
- Denosumab label "Denosumab".
- Denosumab label "دينوسوماب".
- Denosumab label "デノスマブ".
- Denosumab sameAs Denosumab.
- Denosumab sameAs Denosumab.
- Denosumab sameAs Denosumab.
- Denosumab sameAs Denosumab.
- Denosumab sameAs デノスマブ.
- Denosumab sameAs m.027v8r1.
- Denosumab sameAs Q408283.
- Denosumab sameAs Q408283.
- Denosumab sameAs Denosumab.
- Denosumab wasDerivedFrom Denosumab?oldid=601063328.
- Denosumab homepage www.prolia.com.
- Denosumab isPrimaryTopicOf Denosumab.