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- Desmethylclozapine abstract "N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. Unlike clozapine, it possesses intrinsic activity at the D2/D3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox. Notably, NDMC has also been shown to act as a potent and efficacious agonist at the M1 and δ-opioid receptors, unlike clozapine as well. Therefore, NDMC is considered a delta-opioid agonist. It was hypothesized that on account of these unique actions, NDMC might underlie the clinical superiority of clozapine over other antipsychotics. However, clinical trials found NMDC itself ineffective in the treatment of schizophrenia. This may be because it possesses relatively low D2/D3 occupancy compared to 5-HT2 (<15% versus 64-79% at a dose of 10–60 mg/kg s.c. in animal studies). In any case, though not useful in the treatment of positive symptoms on its own, it cannot be ruled out that NDMC may contribute to the improvement of cognitive and/or negative symptoms with clozapine.".
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- Desmethylclozapine iupacName "8-chloro-11-piperazin-1-yl-5H-dibenzo[b,e][1,4]diazepine".
- Desmethylclozapine pubchem "2820".
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- Desmethylclozapine legalStatus "Uncontrolled".
- Desmethylclozapine molecularWeight "312.8".
- Desmethylclozapine n "4".
- Desmethylclozapine pubchem "2820".
- Desmethylclozapine routesOfAdministration Mouth.
- Desmethylclozapine smiles "Clc1ccc2Nc4ccccc4C/N3CCNCC3".
- Desmethylclozapine unii "1".
- Desmethylclozapine subject Category:Antipsychotics.
- Desmethylclozapine subject Category:Delta-opioid_agonists.
- Desmethylclozapine subject Category:Dibenzodiazepines.
- Desmethylclozapine subject Category:Mu-opioid_agonists.
- Desmethylclozapine subject Category:Organochlorides.
- Desmethylclozapine subject Category:Piperazines.
- Desmethylclozapine type Agent114778436.
- Desmethylclozapine type Antipsychotics.
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- Desmethylclozapine type Piperazine103946814.
- Desmethylclozapine type Piperazines.
- Desmethylclozapine type PsychotropicAgent104017429.
- Desmethylclozapine type Sedative-hypnotic104166841.
- Desmethylclozapine type Sedative104166553.
- Desmethylclozapine type Substance100020090.
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- Desmethylclozapine comment "N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. Unlike clozapine, it possesses intrinsic activity at the D2/D3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox. Notably, NDMC has also been shown to act as a potent and efficacious agonist at the M1 and δ-opioid receptors, unlike clozapine as well. Therefore, NDMC is considered a delta-opioid agonist.".
- Desmethylclozapine label "Desmethylclozapine".
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- Desmethylclozapine sameAs Q5264612.
- Desmethylclozapine sameAs Desmethylclozapine.
- Desmethylclozapine wasDerivedFrom Desmethylclozapine?oldid=590985470.
- Desmethylclozapine depiction N-Desmethylclozapine.png.
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