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- Dexfenfluramine abstract "Dexfenfluramine, marketed as dexfenfluramine hydrochloride under the name Redux, is a serotoninergic anorectic drug: it reduces appetite by increasing the amount of extracellular serotonin in the brain. It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects.Dexfenfluramine was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn and it was retired from the market in 1997. After it was removed in the US, dexfenfluramine was also pulled out in other global markets. It was later superseded by sibutramine, which, although initially considered a safer alternative to both dexfenfluramine and fenfluramine[citation needed], was likewise removed from the US market in 2010.The drug was manufactured by Interneuron Pharmaceuticals, a company co-founded by Richard Wurtman, aimed at marketing discoveries by Massachusetts Institute of Technology scientists. In the case of Redux, Interneuron's manufacture was under licence to Wyeth-Ayerst Laboratories. Although at the time of its release, some optimism prevailed that it might herald a new approach[citation needed], there remained some reservations amongst neurologists, twenty-two of whom petitioned the FDA to delay approval[citation needed]. Their concern was based on the work of George A. Ricaurte, whose techniques and conclusions were later questioned.In actuality, most conversant with the discussion felt that dexfenfuramine's only advantage was patent protection for its licensed companies. Racemic fenfluramine was far cheaper.".
- Dexfenfluramine atcPrefix "A08".
- Dexfenfluramine atcSuffix "AA04".
- Dexfenfluramine casNumber "3239-44-9".
- Dexfenfluramine chEBI "439329".
- Dexfenfluramine drugbank "DB01191".
- Dexfenfluramine fdaUniiCode "E35R3G56OV".
- Dexfenfluramine iupacName "(S)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine".
- Dexfenfluramine pubchem "66265".
- Dexfenfluramine thumbnail Dexfenfluramine.svg?width=300.
- Dexfenfluramine wikiPageExternalLink fenphenpr81597.htm.
- Dexfenfluramine wikiPageExternalLink fenphenqa2.htm.
- Dexfenfluramine wikiPageExternalLink pim939.htm.
- Dexfenfluramine wikiPageExternalLink lutwak.html.
- Dexfenfluramine wikiPageExternalLink dexfen.htm.
- Dexfenfluramine wikiPageID "4635792".
- Dexfenfluramine wikiPageRevisionID "597970934".
- Dexfenfluramine atcPrefix "A08".
- Dexfenfluramine atcSuffix "AA04".
- Dexfenfluramine c "12".
- Dexfenfluramine casNumber "3239".
- Dexfenfluramine chebi "439329".
- Dexfenfluramine chembl "248702".
- Dexfenfluramine chemspiderid "59646".
- Dexfenfluramine drugbank "DB01191".
- Dexfenfluramine eliminationHalfLife "72000.0".
- Dexfenfluramine f "3".
- Dexfenfluramine h "16".
- Dexfenfluramine hasPhotoCollection Dexfenfluramine.
- Dexfenfluramine inchi "1".
- Dexfenfluramine inchikey "DBGIVFWFUFKIQN-VIFPVBQEBO".
- Dexfenfluramine iupacName "-N-Ethyl-1-[3-phenyl]-propan-2-amine".
- Dexfenfluramine kegg "D07805".
- Dexfenfluramine legalStatus "Withdrawn from market".
- Dexfenfluramine legalUs "Schedule IV".
- Dexfenfluramine medlineplus "a682088".
- Dexfenfluramine molecularWeight "231.257".
- Dexfenfluramine n "1".
- Dexfenfluramine proteinBound "36.0".
- Dexfenfluramine pubchem "66265".
- Dexfenfluramine smiles "FCc1ccccC[C@@H]C".
- Dexfenfluramine stdinchi "1".
- Dexfenfluramine stdinchikey "DBGIVFWFUFKIQN-VIFPVBQESA-N".
- Dexfenfluramine unii "E35R3G56OV".
- Dexfenfluramine verifiedrevid "464367204".
- Dexfenfluramine subject Category:Amphetamines.
- Dexfenfluramine subject Category:Antiobesity_drugs.
- Dexfenfluramine subject Category:Enantiopure_drugs.
- Dexfenfluramine subject Category:Organofluorides.
- Dexfenfluramine subject Category:Serotonin_receptor_agonists.
- Dexfenfluramine subject Category:Withdrawn_drugs.
- Dexfenfluramine type Agent114778436.
- Dexfenfluramine type Amphetamine102704153.
- Dexfenfluramine type Amphetamines.
- Dexfenfluramine type AntiobesityDrugs.
- Dexfenfluramine type CausalAgent100007347.
- Dexfenfluramine type Drug103247620.
- Dexfenfluramine type DrugOfAbuse103248958.
- Dexfenfluramine type EnantiopureDrugs.
- Dexfenfluramine type Matter100020827.
- Dexfenfluramine type PhysicalEntity100001930.
- Dexfenfluramine type Stimulant104320126.
- Dexfenfluramine type Substance100020090.
- Dexfenfluramine type WithdrawnDrugs.
- Dexfenfluramine type Drug.
- Dexfenfluramine type DrugProduct.
- Dexfenfluramine type FunctionalSubstance.
- Dexfenfluramine comment "Dexfenfluramine, marketed as dexfenfluramine hydrochloride under the name Redux, is a serotoninergic anorectic drug: it reduces appetite by increasing the amount of extracellular serotonin in the brain. It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects.Dexfenfluramine was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss.".
- Dexfenfluramine label "Dexfenfluramina".
- Dexfenfluramine label "Dexfenfluramine".
- Dexfenfluramine label "Dexfenfluramine".
- Dexfenfluramine sameAs Dexfenfluramina.
- Dexfenfluramine sameAs Dexfenfluramine.
- Dexfenfluramine sameAs m.0cdsqx.
- Dexfenfluramine sameAs Q3025599.
- Dexfenfluramine sameAs Q3025599.
- Dexfenfluramine sameAs DB01191.
- Dexfenfluramine sameAs Dexfenfluramine.
- Dexfenfluramine wasDerivedFrom Dexfenfluramine?oldid=597970934.
- Dexfenfluramine depiction Dexfenfluramine.svg.
- Dexfenfluramine isPrimaryTopicOf Dexfenfluramine.