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- Dihydrodipicolinate_synthase abstract "In enzymology, a dihydrodipicolinate synthase (EC 4.3.3.7) is an enzyme that catalyzes the chemical reactionL-aspartate 4-semialdehyde + pyruvate (S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2OThus, the two substrates of this enzyme are L-aspartate 4-semialdehyde and pyruvate, whereas its two products are (S)-2,3-dihydropyridine-2,6-dicarboxylate and H2O.This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]. Other names in common use include dihydropicolinate synthetase (DHDPS), dihydrodipicolinic acid synthase, L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and, and cyclizing). This enzyme participates in lysine biosynthesis. Dihydropicolinate synthase is the key enzyme in lysine biosynthesis via the diaminopimelate pathway of prokaryotes, some phycomycetes and higher plants. The enzyme catalyses the condensation of L-aspartate-beta- semialdehyde and pyruvate to dihydropicolinic acid via a ping-pong mechanism in which pyruvate binds to the enzyme by forming a Schiff base with a lysine residue. Three other proteins are structurally related to DHDPS and probably also act via a similar catalytic mechanism. These are Escherichia coli N-acetylneuraminate lyase (EC 4.1.3.3) (gene nanA), which catalyses the condensation of N-acetyl-D-mannosamine and pyruvate to form N-acetylneuraminate; Rhizobium meliloti (Sinorhizobium meliloti) protein mosA, which is involved in the biosynthesis of the rhizopine 3-o-methyl-scyllo-inosamine; and E. coli hypothetical protein yjhH. The sequences of DHDPS from different sources are well-conserved. The structure takes the form of a homotetramer, in which 2 monomers are related by an approximate 2-fold symmetry. Each monomer comprises 2 domains: an 8-fold alpha-/beta-barrel, and a C-terminal alpha-helical domain. The fold resembles that of N-acetylneuraminate lyase. The active site lysine is located in the barrel domain, and has access via 2 channels on the C-terminal side of the barrel.".
- Dihydrodipicolinate_synthase ecNumber "4.3.3.7".
- Dihydrodipicolinate_synthase thumbnail PDB_1xky_EBI.jpg?width=300.
- Dihydrodipicolinate_synthase wikiPageID "14334259".
- Dihydrodipicolinate_synthase wikiPageRevisionID "598892460".
- Dihydrodipicolinate_synthase caption "crystal structure of dihydrodipicolinate synthase dapa-2 from bacillus anthracis at 1.94a resolution.".
- Dihydrodipicolinate_synthase casNumber "9055".
- Dihydrodipicolinate_synthase ecNumber "4.3".
- Dihydrodipicolinate_synthase goCode "8840".
- Dihydrodipicolinate_synthase hasPhotoCollection Dihydrodipicolinate_synthase.
- Dihydrodipicolinate_synthase interpro "IPR002220".
- Dihydrodipicolinate_synthase iubmbEcNumber "4".
- Dihydrodipicolinate_synthase name "Dihydrodipicolinate synthetase family".
- Dihydrodipicolinate_synthase name "dihydrodipicolinate synthase".
- Dihydrodipicolinate_synthase pfam "PF00701".
- Dihydrodipicolinate_synthase pfamClan "CL0036".
- Dihydrodipicolinate_synthase prosite "PDOC00569".
- Dihydrodipicolinate_synthase scop "1".
- Dihydrodipicolinate_synthase symbol "DHDPS".
- Dihydrodipicolinate_synthase subject Category:EC_4.2.1.
- Dihydrodipicolinate_synthase subject Category:Enzymes_of_known_structure.
- Dihydrodipicolinate_synthase subject Category:Protein_domains.
- Dihydrodipicolinate_synthase type Abstraction100002137.
- Dihydrodipicolinate_synthase type Activator114723079.
- Dihydrodipicolinate_synthase type Attribute100024264.
- Dihydrodipicolinate_synthase type Catalyst114723628.
- Dihydrodipicolinate_synthase type Chemical114806838.
- Dihydrodipicolinate_synthase type Compound114818238.
- Dihydrodipicolinate_synthase type Environment113934596.
- Dihydrodipicolinate_synthase type Enzyme114732946.
- Dihydrodipicolinate_synthase type EnzymesOfKnownStructure.
- Dihydrodipicolinate_synthase type Macromolecule114944888.
- Dihydrodipicolinate_synthase type Material114580897.
- Dihydrodipicolinate_synthase type Matter100020827.
- Dihydrodipicolinate_synthase type Molecule114682133.
- Dihydrodipicolinate_synthase type OrganicCompound114727670.
- Dihydrodipicolinate_synthase type Part113809207.
- Dihydrodipicolinate_synthase type PhysicalEntity100001930.
- Dihydrodipicolinate_synthase type Protein114728724.
- Dihydrodipicolinate_synthase type ProteinDomains.
- Dihydrodipicolinate_synthase type Relation100031921.
- Dihydrodipicolinate_synthase type Situation113927383.
- Dihydrodipicolinate_synthase type Sphere114514039.
- Dihydrodipicolinate_synthase type State100024720.
- Dihydrodipicolinate_synthase type Substance100019613.
- Dihydrodipicolinate_synthase type Thing100002452.
- Dihydrodipicolinate_synthase type Unit109465459.
- Dihydrodipicolinate_synthase type Biomolecule.
- Dihydrodipicolinate_synthase type Enzyme.
- Dihydrodipicolinate_synthase type BiologicalObject.
- Dihydrodipicolinate_synthase comment "In enzymology, a dihydrodipicolinate synthase (EC 4.3.3.7) is an enzyme that catalyzes the chemical reactionL-aspartate 4-semialdehyde + pyruvate (S)-2,3-dihydropyridine-2,6-dicarboxylate + 2 H2OThus, the two substrates of this enzyme are L-aspartate 4-semialdehyde and pyruvate, whereas its two products are (S)-2,3-dihydropyridine-2,6-dicarboxylate and H2O.This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds.".
- Dihydrodipicolinate_synthase label "Dihydrodipicolinate synthase".
- Dihydrodipicolinate_synthase sameAs m.03d0vh7.
- Dihydrodipicolinate_synthase sameAs Q5276424.
- Dihydrodipicolinate_synthase sameAs Q5276424.
- Dihydrodipicolinate_synthase sameAs 2659.
- Dihydrodipicolinate_synthase sameAs Dihydrodipicolinate_synthase.
- Dihydrodipicolinate_synthase wasDerivedFrom Dihydrodipicolinate_synthase?oldid=598892460.
- Dihydrodipicolinate_synthase depiction PDB_1xky_EBI.jpg.
- Dihydrodipicolinate_synthase isPrimaryTopicOf Dihydrodipicolinate_synthase.
- Dihydrodipicolinate_synthase name "dihydrodipicolinate synthase".