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- Dihydropteroate_synthase abstract "Dihydropteroate synthase is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor. (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate (PABA) diphosphate + dihydropteroate.All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. Most microorganisms must synthesize folate de novo because they lack the active transport system of higher vertebrate cells that allows these organisms to use dietary folates. Proteins containing this domain include dihydropteroate synthase (EC 2.5.1.15) as well as a group of methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulphur protein methyltransferase (MeTr) Q46389 that catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation.Dihydropteroate synthase (EC 2.5.1.15) (DHPS) catalyses the condensation of 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three-step pathway leading from 6-hydroxymethyl-7,8-dihydropterin to 7,8-dihydrofolate. DHPS is the target of sulphonamides, which are substrate analogues that compete with para-aminobenzoic acid. Bacterial DHPS (gene sul or folP) is a protein of about 275 to 315 amino acid residues that is either chromosomally encoded or found on various antibiotic resistance plasmids. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas).".
- Dihydropteroate_synthase ecNumber "2.5.1.15".
- Dihydropteroate_synthase thumbnail THFsynthesispathway.png?width=300.
- Dihydropteroate_synthase wikiPageID "9268243".
- Dihydropteroate_synthase wikiPageRevisionID "559458994".
- Dihydropteroate_synthase caption "Tetrahydrofolate synthesis pathway".
- Dihydropteroate_synthase casNumber "9055".
- Dihydropteroate_synthase ecNumber "2.5".
- Dihydropteroate_synthase goCode "4156".
- Dihydropteroate_synthase hasPhotoCollection Dihydropteroate_synthase.
- Dihydropteroate_synthase interpro "IPR000489".
- Dihydropteroate_synthase iubmbEcNumber "2".
- Dihydropteroate_synthase name "Dihydropteroate synthase".
- Dihydropteroate_synthase name "Pterin binding enzyme".
- Dihydropteroate_synthase pdb "A:28-230 A:28-230 B:28-230 A:28-230 A:28-230 B:9-210 A:9-210 A:11-220 :20-228 :20-228 :20-228 A:509-774 B:315-515 B:315-515 A:315-515 A:315-515 B:315-515 A:315-515 A:1-206".
- Dihydropteroate_synthase pfam "PF00809".
- Dihydropteroate_synthase prosite "PDOC00630".
- Dihydropteroate_synthase scop "1".
- Dihydropteroate_synthase symbol "Pterin_bind".
- Dihydropteroate_synthase subject Category:EC_2.5.1.
- Dihydropteroate_synthase type Biomolecule.
- Dihydropteroate_synthase type Enzyme.
- Dihydropteroate_synthase type BiologicalObject.
- Dihydropteroate_synthase comment "Dihydropteroate synthase is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor. (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate (PABA) diphosphate + dihydropteroate.All organisms require reduced folate cofactors for the synthesis of a variety of metabolites.".
- Dihydropteroate_synthase label "Dihydropteroate synthase".
- Dihydropteroate_synthase sameAs m.0282c0b.
- Dihydropteroate_synthase sameAs Q5276443.
- Dihydropteroate_synthase sameAs Q5276443.
- Dihydropteroate_synthase wasDerivedFrom Dihydropteroate_synthase?oldid=559458994.
- Dihydropteroate_synthase depiction THFsynthesispathway.png.
- Dihydropteroate_synthase isPrimaryTopicOf Dihydropteroate_synthase.
- Dihydropteroate_synthase name "Dihydropteroate synthase".