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- Discodermolide abstract "(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea marine sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.".
- Discodermolide iupacName "(+)-Discodermolide".
- Discodermolide thumbnail Structure_of_discodermolide.png?width=300.
- Discodermolide wikiPageExternalLink 8209sci2.html.
- Discodermolide wikiPageExternalLink jiang-sem.pdf.
- Discodermolide wikiPageExternalLink 03March.shtm.
- Discodermolide wikiPageID "3325951".
- Discodermolide wikiPageRevisionID "598693921".
- Discodermolide hasPhotoCollection Discodermolide.
- Discodermolide imagefile "structure of discodermolide.png".
- Discodermolide imagename "-Discodermolide".
- Discodermolide iupacname "-Discodermolide".
- Discodermolide name "Discodermolide".
- Discodermolide verifiedfields "changed".
- Discodermolide verifiedrevid "477388975".
- Discodermolide subject Category:Experimental_cancer_drugs.
- Discodermolide subject Category:Total_synthesis.
- Discodermolide type Agent114778436.
- Discodermolide type Antineoplastic102722458.
- Discodermolide type CausalAgent100007347.
- Discodermolide type CytotoxicDrug103157987.
- Discodermolide type Drug103247620.
- Discodermolide type ExperimentalCancerDrugs.
- Discodermolide type Matter100020827.
- Discodermolide type Medicine103740161.
- Discodermolide type PhysicalEntity100001930.
- Discodermolide type Substance100020090.
- Discodermolide type ChemicalCompound.
- Discodermolide type ChemicalSubstance.
- Discodermolide type ChemicalSubstanceType.
- Discodermolide type ChemicalObject.
- Discodermolide type Thing.
- Discodermolide comment "(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea marine sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines.".
- Discodermolide label "Discodermolida".
- Discodermolide label "Discodermolide".
- Discodermolide sameAs Discodermolida.
- Discodermolide sameAs Diskodermolida.
- Discodermolide sameAs m.095ymb.
- Discodermolide sameAs Q2920456.
- Discodermolide sameAs Q2920456.
- Discodermolide sameAs Discodermolide.
- Discodermolide wasDerivedFrom Discodermolide?oldid=598693921.
- Discodermolide depiction Structure_of_discodermolide.png.
- Discodermolide isPrimaryTopicOf Discodermolide.
- Discodermolide name "Discodermolide".