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- Discovery_and_development_of_antiandrogens abstract "In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. New research also suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.Current antiandrogens are small molecule antiandrogens and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.".
- Discovery_and_development_of_antiandrogens thumbnail Androgen_receptor.png?width=300.
- Discovery_and_development_of_antiandrogens wikiPageExternalLink androgendb.mcgill.ca.
- Discovery_and_development_of_antiandrogens wikiPageID "32986449".
- Discovery_and_development_of_antiandrogens wikiPageRevisionID "605600228".
- Discovery_and_development_of_antiandrogens align "center".
- Discovery_and_development_of_antiandrogens alt "Bicalutamide".
- Discovery_and_development_of_antiandrogens alt "Cyproterone acetate".
- Discovery_and_development_of_antiandrogens alt "Hydroxyflutamide".
- Discovery_and_development_of_antiandrogens alt "Nilutamide".
- Discovery_and_development_of_antiandrogens caption "Bicalutamide".
- Discovery_and_development_of_antiandrogens caption "Cyproterone acetate".
- Discovery_and_development_of_antiandrogens caption "Hydroxyflutamide".
- Discovery_and_development_of_antiandrogens caption "Nilutamide".
- Discovery_and_development_of_antiandrogens footer "Figure 7: Basic structures of current antiandrogens".
- Discovery_and_development_of_antiandrogens hasPhotoCollection Discovery_and_development_of_antiandrogens.
- Discovery_and_development_of_antiandrogens headerAlign "center".
- Discovery_and_development_of_antiandrogens image "Bicalutamide_-_R2.jpg".
- Discovery_and_development_of_antiandrogens image "Hydroxyflutamide_-_R.jpg".
- Discovery_and_development_of_antiandrogens image "Nilutamide_-_R.jpg".
- Discovery_and_development_of_antiandrogens width "140".
- Discovery_and_development_of_antiandrogens width "160".
- Discovery_and_development_of_antiandrogens width "170".
- Discovery_and_development_of_antiandrogens width "300".
- Discovery_and_development_of_antiandrogens subject Category:Antiandrogens.
- Discovery_and_development_of_antiandrogens subject Category:Articles_created_via_the_Article_Wizard.
- Discovery_and_development_of_antiandrogens subject Category:Cancer_research.
- Discovery_and_development_of_antiandrogens comment "In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases.".
- Discovery_and_development_of_antiandrogens label "Discovery and development of antiandrogens".
- Discovery_and_development_of_antiandrogens sameAs m.0xnnx04.
- Discovery_and_development_of_antiandrogens sameAs Q5281996.
- Discovery_and_development_of_antiandrogens sameAs Q5281996.
- Discovery_and_development_of_antiandrogens wasDerivedFrom Discovery_and_development_of_antiandrogens?oldid=605600228.
- Discovery_and_development_of_antiandrogens depiction Androgen_receptor.png.
- Discovery_and_development_of_antiandrogens isPrimaryTopicOf Discovery_and_development_of_antiandrogens.
