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• Drug_interaction abstract "A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.".
• Drug_interaction thumbnail Drug_ampoule_JPN.jpg?width=300.
• Drug_interaction wikiPageExternalLink cap2_farmacocinet.pdf.
• Drug_interaction wikiPageExternalLink table.htm.
• Drug_interaction wikiPageExternalLink Arzneimittel-Check.
• Drug_interaction wikiPageExternalLink revis3a.html.
• Drug_interaction wikiPageExternalLink ddiguide.
• Drug_interaction wikiPageExternalLink www.drug-interactions.eu.
• Drug_interaction wikiPageExternalLink www.drugdigest.org.
• Drug_interaction wikiPageExternalLink drug_interactions.html.
• Drug_interaction wikiPageExternalLink drug_interactions_checker.
• Drug_interaction wikiPageExternalLink ucm163354.htm.
• Drug_interaction wikiPageExternalLink medlineplus.
• Drug_interaction wikiPageExternalLink drug%20interaction2e.pdf.
• Drug_interaction wikiPageExternalLink www.vademecum.es.
• Drug_interaction wikiPageID "1099396".
• Drug_interaction wikiPageRevisionID "605182759".
• Drug_interaction hasPhotoCollection Drug_interaction.
• Drug_interaction subject Category:Clinical_pharmacology.
• Drug_interaction subject Category:Drugs.
• Drug_interaction subject Category:Pharmacology.
• Drug_interaction comment "A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction).".
• Drug_interaction label "Arzneimittelwechselwirkung".
• Drug_interaction label "Drug interaction".
• Drug_interaction label "Interacción farmacológica".
• Drug_interaction label "Interakcja farmakologiczna".
• Drug_interaction label "Interação medicamentosa".
• Drug_interaction label "تداخل دوائي".
• Drug_interaction label "薬物相互作用".
• Drug_interaction sameAs Lékové_interakce.
• Drug_interaction sameAs Arzneimittelwechselwirkung.
• Drug_interaction sameAs Interacción_farmacológica.
• Drug_interaction sameAs Elkarrekintza_farmakologiko.
• Drug_interaction sameAs 薬物相互作用.
• Drug_interaction sameAs Interakcja_farmakologiczna.
• Drug_interaction sameAs Interação_medicamentosa.
• Drug_interaction sameAs m.045yj_.
• Drug_interaction sameAs Q718753.
• Drug_interaction sameAs Q718753.
• Drug_interaction wasDerivedFrom Drug_interaction?oldid=605182759.
• Drug_interaction depiction Drug_ampoule_JPN.jpg.
• Drug_interaction isPrimaryTopicOf Drug_interaction.