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- DyP-type_peroxidase_family abstract "In molecular biology, the DyP-type peroxidase family is a family of haem peroxidase enzymes.Haem peroxidases were originally divided into two superfamilies, namely, the animal peroxidases and the plant peroxidases (which are subdivided into class I, II and III), which include fungal (class II) and bacterial peroxidases. The DyP (for dye de-colourising peroxidase) family constitutes a novel class of haem peroxidase. Because these enzymes were derived from fungal sources, the DyP family was thought to be structurally related to the class II secretory fungal peroxidases. However, the DyP family exhibits only low sequence similarity to classical fungal peroxidases, such as LiP and MnP, and does not contain the conserved proximal and distal histidines and an essential arginine found in other plant peroxidase superfamily members.DyP proteins have several characteristics that distinguish them from all other peroxidases, including a particularly wide substrate specificity, a lack of homology to most other peroxidases, and the ability to function well under much lower pH conditions compared with the other plant peroxidases. In terms of substrate specificity, DyP degrades the typical peroxidase substrates, but also degrades hydroxyl-free anthraquinone (many dyes are derived from anthraquinone compounds).Crystal structures of DyP family members reveal two domains, each one adopting a ferredoxin-like fold. The proteins consist of an N-terminal domain and a C-terminal domain likely to be related by a duplication of an ancestral gene, as inferred from the conserved topology of the domains. The haem iron is penta-coordinated, with the protein contributing a conserved histidine ligand to the iron centre. A conserved Asp most likely acts as a proton donor/acceptor and takes the place of the catalytic histidine used by plant peroxidases. This Asp substitution helps explain why the DyP family is active at low pH.".
- DyP-type_peroxidase_family symbol "Dyp_perox".
- DyP-type_peroxidase_family thumbnail PDB_2gvk_EBI.jpg?width=300.
- DyP-type_peroxidase_family wikiPageID "32636003".
- DyP-type_peroxidase_family wikiPageRevisionID "591122619".
- DyP-type_peroxidase_family caption "crystal structure of a dye-decolorizing peroxidase from bacteroides thetaiotaomicron vpi-5482 at 1.6 a resolution".
- DyP-type_peroxidase_family hasPhotoCollection DyP-type_peroxidase_family.
- DyP-type_peroxidase_family interpro "IPR006314".
- DyP-type_peroxidase_family name "Dyp-type peroxidase family".
- DyP-type_peroxidase_family pfam "PF04261".
- DyP-type_peroxidase_family pfamClan "CL0032".
- DyP-type_peroxidase_family symbol "Dyp_perox".
- DyP-type_peroxidase_family subject Category:Protein_families.
- DyP-type_peroxidase_family type Abstraction100002137.
- DyP-type_peroxidase_family type Family108078020.
- DyP-type_peroxidase_family type Group100031264.
- DyP-type_peroxidase_family type Organization108008335.
- DyP-type_peroxidase_family type ProteinFamilies.
- DyP-type_peroxidase_family type SocialGroup107950920.
- DyP-type_peroxidase_family type Unit108189659.
- DyP-type_peroxidase_family type YagoLegalActor.
- DyP-type_peroxidase_family type YagoLegalActorGeo.
- DyP-type_peroxidase_family type YagoPermanentlyLocatedEntity.
- DyP-type_peroxidase_family type Biomolecule.
- DyP-type_peroxidase_family type Protein.
- DyP-type_peroxidase_family type BiologicalObject.
- DyP-type_peroxidase_family comment "In molecular biology, the DyP-type peroxidase family is a family of haem peroxidase enzymes.Haem peroxidases were originally divided into two superfamilies, namely, the animal peroxidases and the plant peroxidases (which are subdivided into class I, II and III), which include fungal (class II) and bacterial peroxidases. The DyP (for dye de-colourising peroxidase) family constitutes a novel class of haem peroxidase.".
- DyP-type_peroxidase_family label "DyP-type peroxidase family".
- DyP-type_peroxidase_family sameAs m.0h3t16r.
- DyP-type_peroxidase_family sameAs Q5318381.
- DyP-type_peroxidase_family sameAs Q5318381.
- DyP-type_peroxidase_family sameAs DyP-type_peroxidase_family.
- DyP-type_peroxidase_family wasDerivedFrom DyP-type_peroxidase_family?oldid=591122619.
- DyP-type_peroxidase_family depiction PDB_2gvk_EBI.jpg.
- DyP-type_peroxidase_family isPrimaryTopicOf DyP-type_peroxidase_family.