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- E2F1 abstract "Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.".
- E2F1 entrezgene "1869".
- E2F1 wikiPageExternalLink abstract.
- E2F1 wikiPageID "13980220".
- E2F1 wikiPageRevisionID "591125776".
- E2F1 hasPhotoCollection E2F1.
- E2F1 requireManualInspection "no".
- E2F1 summaryText "The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins , a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.".
- E2F1 updateCitations "yes".
- E2F1 updatePage "yes".
- E2F1 updateProteinBox "yes".
- E2F1 updateSummary "yes".
- E2F1 subject Category:Transcription_factors.
- E2F1 type Biomolecule.
- E2F1 type Protein.
- E2F1 type BiologicalObject.
- E2F1 comment "Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family.".
- E2F1 label "E2F1".
- E2F1 label "E2F1".
- E2F1 label "E2F1".
- E2F1 sameAs E2F1.
- E2F1 sameAs E2F1.
- E2F1 sameAs m.03cq11r.
- E2F1 sameAs Q5322375.
- E2F1 sameAs Q5322375.
- E2F1 wasDerivedFrom E2F1?oldid=591125776.
- E2F1 isPrimaryTopicOf E2F1.