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- ESCRT abstract "The endosomal sorting complexes required for transport (ESCRT) machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes bending/budding away from the cytoplasm. These ESCRT components have been isolated and studied in a number of organisms including yeast and humans.The ESCRT machinery plays a vital role in a number of cellular processes including multivesicular body (MVB) biogenesis, cellular abscission, and viral budding. Multivesicular body (MVB) biogenesis is a process in which ubiquitin tagged proteins enter organelles called endosomes via the formation of vesicles. This process is essential for cells to destroy misfolded and damaged proteins. Without ESCRT machinery, these proteins can build up and lead to neurodegenerative disease. For example, abnormalities in ESCRT-III components can lead to neurological disorders such as hereditary spastic paraplegia (HSP). Cellular abscission, the process by which the membrane connecting two daughter cells is cleaved, is also mediated by ESCRT machinery. Without the ESCRT complexes, daughter cells could not separate and abnormal cells containing twice the amount of DNA would be generated. These cells would inevitably be destroyed through a process known as apoptosis. Lastly, viral budding, or the process by which specific types of viruses exit cells, may not occur in the absence of ESCRT machinery. This would inevitably prevent viruses from spreading from cell to cell.".
- ESCRT thumbnail ESCRT_Machinery-Corrected.png?width=300.
- ESCRT wikiPageID "21082137".
- ESCRT wikiPageRevisionID "601035008".
- ESCRT hasPhotoCollection ESCRT.
- ESCRT subject Category:Cell_anatomy.
- ESCRT subject Category:Organelles.
- ESCRT type Abstraction100002137.
- ESCRT type Chemical114806838.
- ESCRT type Compound114818238.
- ESCRT type Macromolecule114944888.
- ESCRT type Material114580897.
- ESCRT type Matter100020827.
- ESCRT type Molecule114682133.
- ESCRT type MoonlightingProteins.
- ESCRT type OrganicCompound114727670.
- ESCRT type Part113809207.
- ESCRT type PhysicalEntity100001930.
- ESCRT type Protein114728724.
- ESCRT type Relation100031921.
- ESCRT type Substance100019613.
- ESCRT type Thing100002452.
- ESCRT type Unit109465459.
- ESCRT comment "The endosomal sorting complexes required for transport (ESCRT) machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes bending/budding away from the cytoplasm.".
- ESCRT label "ESCRT".
- ESCRT sameAs m.05c2jvz.
- ESCRT sameAs Q5324129.
- ESCRT sameAs Q5324129.
- ESCRT sameAs ESCRT.
- ESCRT wasDerivedFrom ESCRT?oldid=601035008.
- ESCRT depiction ESCRT_Machinery-Corrected.png.
- ESCRT isPrimaryTopicOf ESCRT.