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- EVH1_domain abstract "The EVH1 domain (also known as the WH1, RanBP1-WASP, or enabled/VASP homology 1 domain) is an evolutionary conserved protein domain.The EVH1 domain is found in multi-domain Ena/Vasp homology proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity, further interactions then form between flanking residues.WASP family proteins contain an EVH1 (WH1) in their N-terminus which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N-terminal region, which seems to bind a different sequence motif present in the C-terminal part of RanGTP protein.Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin (PH) domain. The overall fold consists of a compact parallel beta-sandwich, closed along one edge by a long alpha helix. A highly conserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecule's target ligands.".
- EVH1_domain symbol "EVH1".
- EVH1_domain thumbnail PDB_1mke_EBI.jpg?width=300.
- EVH1_domain wikiPageID "32016793".
- EVH1_domain wikiPageRevisionID "599324134".
- EVH1_domain caption "structure of the n-wasp evh1 domain-wip complex".
- EVH1_domain hasPhotoCollection EVH1_domain.
- EVH1_domain interpro "IPR000697".
- EVH1_domain name "EVH1".
- EVH1_domain pfam "PF00568".
- EVH1_domain pfamClan "CL0266".
- EVH1_domain scop "1".
- EVH1_domain smart "WH1".
- EVH1_domain symbol "EVH1".
- EVH1_domain subject Category:EVH1_domain.
- EVH1_domain subject Category:Protein_domains.
- EVH1_domain type Biomolecule.
- EVH1_domain type Protein.
- EVH1_domain type BiologicalObject.
- EVH1_domain comment "The EVH1 domain (also known as the WH1, RanBP1-WASP, or enabled/VASP homology 1 domain) is an evolutionary conserved protein domain.The EVH1 domain is found in multi-domain Ena/Vasp homology proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation.".
- EVH1_domain label "EVH1 domain".
- EVH1_domain sameAs m.0gwzzh2.
- EVH1_domain sameAs Q5324607.
- EVH1_domain sameAs Q5324607.
- EVH1_domain wasDerivedFrom EVH1_domain?oldid=599324134.
- EVH1_domain depiction PDB_1mke_EBI.jpg.
- EVH1_domain isPrimaryTopicOf EVH1_domain.