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- Eculizumab abstract "Eculizumab (INN and USAN; trade name Soliris) is a humanized monoclonal antibody that is a first-in-class terminal complement inhibitor and the first therapy approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare, progressive, and sometimes life-threatening disease characterized by excessive destruction of red blood cells (hemolysis) and excessive blood clotting. Eculizumab also is the first agent approved for the treatment of atypical hemolytic uremic syndrome (aHUS), an ultra-rare genetic disease that causes abnormal blood clots to form in small blood vessels throughout the body, leading to kidney failure, damage to other vital organs and premature death. It costs approximately £245,700 for ongoing treatment. In clinical trials in patients with PNH, eculizumab was associated with reductions in chronic hemolysis, thromboembolic events, and transfusion requirements, as well as improvements in PNH symptoms, quality of life, and survival. Clinical trials in patients with aHUS demonstrated inhibition of thrombotic microangiopathy (TMA), the formation of blood clots in small blood vessels throughout the body, including normalization of platelets and lactate dehydrogenase (LDH), as well as maintenance or improvement in renal function.Eculizumab was developed by Alexion Pharmaceuticals and is manufactured by Alexion. It was approved by the United States Food and Drug Administration (FDA) on March 16, 2007 for the treatment of PNH, and on September 23, 2011 for the treatment of aHUS. It was approved by the European Medicines Agency for the treatment of PNH on June 20, 2007, and on November 24, 2011 for the treatment of aHUS. Eculizumab is currently being investigated as a potential treatment for other severe, ultra-rare disorders.".
- Eculizumab atcPrefix "L04".
- Eculizumab atcSuffix "AA25".
- Eculizumab casNumber "219685-50-4".
- Eculizumab drugbank "DB01257".
- Eculizumab fdaUniiCode "A3ULP0F556".
- Eculizumab wikiPageExternalLink soliris.net.
- Eculizumab wikiPageExternalLink globulerougeexplose.html.
- Eculizumab wikiPageID "7086253".
- Eculizumab wikiPageRevisionID "603320001".
- Eculizumab atcPrefix "L04".
- Eculizumab atcSuffix "AA25".
- Eculizumab casNumber "219685".
- Eculizumab chembl "1201828".
- Eculizumab chemspiderid "NA".
- Eculizumab drugbank "DB01257".
- Eculizumab eliminationHalfLife "1296000.0".
- Eculizumab hasPhotoCollection Eculizumab.
- Eculizumab legalUk "POM".
- Eculizumab legalUs "Rx-only".
- Eculizumab licenceEu "Soliris".
- Eculizumab licenceUs "Eculizumab".
- Eculizumab mabType "mab".
- Eculizumab molecularWeight "148".
- Eculizumab pregnancyUs "C".
- Eculizumab routesOfAdministration Intravenous_therapy.
- Eculizumab source "zu/o".
- Eculizumab target "Complement protein C5".
- Eculizumab tradename "Soliris".
- Eculizumab type "mab".
- Eculizumab unii "A3ULP0F556".
- Eculizumab verifiedfields "changed".
- Eculizumab verifiedrevid "461092423".
- Eculizumab subject Category:Immunosuppressants.
- Eculizumab subject Category:Orphan_drugs.
- Eculizumab type Agent114778436.
- Eculizumab type CausalAgent100007347.
- Eculizumab type Drug103247620.
- Eculizumab type Immunosuppressant103562958.
- Eculizumab type Immunosuppressants.
- Eculizumab type Matter100020827.
- Eculizumab type Medicine103740161.
- Eculizumab type OrphanDrugs.
- Eculizumab type PhysicalEntity100001930.
- Eculizumab type Substance100020090.
- Eculizumab type Drug.
- Eculizumab type DrugProduct.
- Eculizumab type FunctionalSubstance.
- Eculizumab comment "Eculizumab (INN and USAN; trade name Soliris) is a humanized monoclonal antibody that is a first-in-class terminal complement inhibitor and the first therapy approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare, progressive, and sometimes life-threatening disease characterized by excessive destruction of red blood cells (hemolysis) and excessive blood clotting.".
- Eculizumab label "Eculizumab".
- Eculizumab label "Eculizumab".
- Eculizumab label "Eculizumab".
- Eculizumab label "Eculizumab".
- Eculizumab label "Ekulizumab".
- Eculizumab label "Éculizumab".
- Eculizumab label "إيكوليزوماب".
- Eculizumab label "エクリズマブ".
- Eculizumab sameAs Eculizumab.
- Eculizumab sameAs Éculizumab.
- Eculizumab sameAs Eculizumab.
- Eculizumab sameAs エクリズマブ.
- Eculizumab sameAs Ekulizumab.
- Eculizumab sameAs Eculizumab.
- Eculizumab sameAs m.0h3htt.
- Eculizumab sameAs Q421617.
- Eculizumab sameAs Q421617.
- Eculizumab sameAs DB01257.
- Eculizumab sameAs Eculizumab.
- Eculizumab wasDerivedFrom Eculizumab?oldid=603320001.
- Eculizumab isPrimaryTopicOf Eculizumab.