Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Efaproxiral> ?p ?o. }
Showing items 1 to 55 of
55
with 100 items per page.
- Efaproxiral abstract "Efaproxiral (INN) is an analog of the cholesterol drug bezafibrate developed for the treatment of depression, traumatic brain injury, ischemia, stroke, myocardial infarction, diabetes, hypoxia, sickle cell disease, hypercholesterolemia and as a radio sensitizer. The chemical is a propanoic acid in the class of amphipathic carboxylic acids. Most propanoic acid produced is consumed as a preservative for both animal feed and food for human consumption. One use for efaproxiral is to increase the efficacy of certain chemotherapy drugs which have reduced efficacy against hypoxic tumours, and can thus be made more effective by increased offloading of oxygen into the tumour tissues. No benefit was seen for efaproxiral in phase III clinical trials. The increased oxygenation of tissues could theoretically also produce enhanced exercise capacity in feline, rat and canine models for approximately 100 min. immediately after a high dosage 45 min. intravenous infusion. This has led World Anti-Doping Agency to categorize efaproxiral under a prohibited method to artificially enhance the uptake, transport or delivery of oxygen. There is no existing evidence that efaproxiral can effectively enhance performance in humans. Efaproxiral can be absorbed via transdermal, rectal, inhalation and gastrointestinal routes, though not at plasma concentrations great enough to alter the oxygen-haemoglobin dissociation curve. Efaproxiral is explicitly excluded from the 2012 World Anti-Doping Agency list of Prohibited Substances and is explicitly included in the Prohibited Methods section M1 as a forbidden procedure to alter the oxygen-haemoglobin dissociation curve in order to allosterically modify hemoglobin.".
- Efaproxiral atcPrefix "L01".
- Efaproxiral atcSuffix "XD06".
- Efaproxiral casNumber "131179-95-8".
- Efaproxiral fdaUniiCode "J81E81G364".
- Efaproxiral iupacName "2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic acid".
- Efaproxiral pubchem "122335".
- Efaproxiral thumbnail Efaproxiral.png?width=300.
- Efaproxiral wikiPageID "18477013".
- Efaproxiral wikiPageRevisionID "591159864".
- Efaproxiral atcPrefix "L01".
- Efaproxiral atcSuffix "XD06".
- Efaproxiral c "20".
- Efaproxiral casNumber "131179".
- Efaproxiral chembl "18901".
- Efaproxiral eliminationHalfLife "3600.0".
- Efaproxiral h "23".
- Efaproxiral hasPhotoCollection Efaproxiral.
- Efaproxiral iupacName "2".
- Efaproxiral molecularWeight "341.4".
- Efaproxiral n "1".
- Efaproxiral o "4".
- Efaproxiral pubchem "122335".
- Efaproxiral smiles "CC1=CCC".
- Efaproxiral unii "J81E81G364".
- Efaproxiral verifiedfields "changed".
- Efaproxiral verifiedrevid "387464773".
- Efaproxiral subject Category:Acetanilides.
- Efaproxiral subject Category:Antineoplastic_drugs.
- Efaproxiral subject Category:Phenol_ethers.
- Efaproxiral type Acetanilide102674912.
- Efaproxiral type Acetanilides.
- Efaproxiral type Agent114778436.
- Efaproxiral type Analgesic102707683.
- Efaproxiral type Antineoplastic102722458.
- Efaproxiral type AntineoplasticDrugs.
- Efaproxiral type CausalAgent100007347.
- Efaproxiral type CytotoxicDrug103157987.
- Efaproxiral type Drug103247620.
- Efaproxiral type Matter100020827.
- Efaproxiral type Medicine103740161.
- Efaproxiral type PhysicalEntity100001930.
- Efaproxiral type Substance100020090.
- Efaproxiral type Drug.
- Efaproxiral type DrugProduct.
- Efaproxiral type FunctionalSubstance.
- Efaproxiral comment "Efaproxiral (INN) is an analog of the cholesterol drug bezafibrate developed for the treatment of depression, traumatic brain injury, ischemia, stroke, myocardial infarction, diabetes, hypoxia, sickle cell disease, hypercholesterolemia and as a radio sensitizer. The chemical is a propanoic acid in the class of amphipathic carboxylic acids. Most propanoic acid produced is consumed as a preservative for both animal feed and food for human consumption.".
- Efaproxiral label "Efaproxiral".
- Efaproxiral sameAs m.04f3455.
- Efaproxiral sameAs Q5347186.
- Efaproxiral sameAs Q5347186.
- Efaproxiral sameAs Efaproxiral.
- Efaproxiral wasDerivedFrom Efaproxiral?oldid=591159864.
- Efaproxiral depiction Efaproxiral.png.
- Efaproxiral isPrimaryTopicOf Efaproxiral.