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- Enzyme_promiscuity abstract "Enzyme promiscuity is a property most enzymes possess which is essential for the evolution of new enzymatic functions. Enzymes are remarkably specific catalysts, but often do possess other activities that are very small and are under neutral selection, called promiscuous activities. Despite being ordinarily irrelevant physiologically, under new selective pressures these activities may confer a fitness benefit therefore prompting the evolution of the formerly promiscuous activity to become the new main activity. An example of this is the atrazine chlorohydrolase (atzA encoded) from Pseudomonas sp. ADP which evolved from melamine deaminase (triA encoded), which has very small promiscuous activity towards atrazine, a man-made chemical.".
- Enzyme_promiscuity wikiPageID "38034479".
- Enzyme_promiscuity wikiPageRevisionID "548122108".
- Enzyme_promiscuity group "nb".
- Enzyme_promiscuity hasPhotoCollection Enzyme_promiscuity.
- Enzyme_promiscuity refs "ref|Most authors refer to as promiscuous activities the non-evolved activities and not secondary activities that have been evolved. Consequently, glutathione S-transferases (GSTs) and cytochrome P450 monooxygenases (CYPs) are termed multispecific or broad-specificity enzymes. The ability to catalyse different reactions is often termed catalytic promiscuity or reaction promiscuity, whereas the ability to act upon different substrates is called substrate promiscuity or substrate ambiguity. The term latent has different meanings depending on the author, namely either referring to a promiscuous activity that arises when one or two residues are mutated or simply as a synonym for promiscuous to avoid the latter term. It should be noted that promiscuity here means muddledom, not lechery —the latter is a recently gained meaning of the word.|name=foot".
- Enzyme_promiscuity subject Category:Biomolecules.
- Enzyme_promiscuity subject Category:Catalysis.
- Enzyme_promiscuity subject Category:Enzymes.
- Enzyme_promiscuity subject Category:Metabolism.
- Enzyme_promiscuity subject Category:Process_chemicals.
- Enzyme_promiscuity comment "Enzyme promiscuity is a property most enzymes possess which is essential for the evolution of new enzymatic functions. Enzymes are remarkably specific catalysts, but often do possess other activities that are very small and are under neutral selection, called promiscuous activities.".
- Enzyme_promiscuity label "Enzyme promiscuity".
- Enzyme_promiscuity sameAs m.0pcm1q5.
- Enzyme_promiscuity sameAs Q5381549.
- Enzyme_promiscuity sameAs Q5381549.
- Enzyme_promiscuity wasDerivedFrom Enzyme_promiscuity?oldid=548122108.
- Enzyme_promiscuity isPrimaryTopicOf Enzyme_promiscuity.