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- Epirubicin abstract "Epirubicin is an anthracycline drug used for chemotherapy. It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands.Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage.Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity. Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas.".
- Epirubicin atcPrefix "L01".
- Epirubicin atcSuffix "DB03".
- Epirubicin casNumber "56420-45-2".
- Epirubicin chEBI "47898".
- Epirubicin drugbank "DB00445".
- Epirubicin fdaUniiCode "3Z8479ZZ5X".
- Epirubicin iupacName "(8R,10S)-10-((2S,4S,5R,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione".
- Epirubicin pubchem "41867".
- Epirubicin thumbnail Epirubicin.png?width=300.
- Epirubicin wikiPageExternalLink Epirubicin.htm.
- Epirubicin wikiPageExternalLink description.html.
- Epirubicin wikiPageID "2150359".
- Epirubicin wikiPageRevisionID "565990152".
- Epirubicin atcPrefix "L01".
- Epirubicin atcSuffix "DB03".
- Epirubicin bioavailability "NA".
- Epirubicin c "27".
- Epirubicin casNumber "56420".
- Epirubicin chebi "47898".
- Epirubicin chembl "417".
- Epirubicin chemspiderid "38201".
- Epirubicin drugbank "DB00445".
- Epirubicin excretion "Biliary and renal".
- Epirubicin h "29".
- Epirubicin hasPhotoCollection Epirubicin.
- Epirubicin image "Epirubicin ball-and-stick.png".
- Epirubicin inchi "1".
- Epirubicin inchikey "AOJJSUZBOXZQNB-VTZDEGQIBI".
- Epirubicin iupacName "-10".
- Epirubicin kegg "D07901".
- Epirubicin legalStatus "℞-only , POM".
- Epirubicin medlineplus "a603003".
- Epirubicin metabolism "Hepatic glucuronidation and oxidation".
- Epirubicin molecularWeight "543.519".
- Epirubicin n "1".
- Epirubicin o "11".
- Epirubicin pregnancyCategory "D".
- Epirubicin proteinBound "77.0".
- Epirubicin pubchem "41867".
- Epirubicin routesOfAdministration Intravenous_therapy.
- Epirubicin smiles "O=C2c1cc5cC[C@@]C[C@@H]5O[C@@H]4O[C@H]C".
- Epirubicin stdinchi "1".
- Epirubicin stdinchikey "AOJJSUZBOXZQNB-VTZDEGQISA-N".
- Epirubicin tradename "Ellence".
- Epirubicin unii "3".
- Epirubicin verifiedrevid "461094075".
- Epirubicin watchedfields "changed".
- Epirubicin subject Category:Anthracyclines.
- Epirubicin subject Category:Pfizer.
- Epirubicin subject Category:Topoisomerase_inhibitors.
- Epirubicin type Inhibitor114724436.
- Epirubicin type Matter100020827.
- Epirubicin type PhysicalEntity100001930.
- Epirubicin type Substance100020090.
- Epirubicin type TopoisomeraseInhibitors.
- Epirubicin type Drug.
- Epirubicin type DrugProduct.
- Epirubicin type FunctionalSubstance.
- Epirubicin comment "Epirubicin is an anthracycline drug used for chemotherapy. It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands.Intercalation results in complex formation which inhibits DNA and RNA synthesis.".
- Epirubicin label "Epirubicin".
- Epirubicin label "Epirubicin".
- Epirubicin label "Epirubicyna".
- Epirubicin label "Épirubicine".
- Epirubicin label "Эпирубицин".
- Epirubicin label "エピルビシン".
- Epirubicin sameAs Epirubicin.
- Epirubicin sameAs Épirubicine.
- Epirubicin sameAs エピルビシン.
- Epirubicin sameAs 에피루비신.
- Epirubicin sameAs Epirubicyna.
- Epirubicin sameAs m.06qh3b.
- Epirubicin sameAs Q425122.
- Epirubicin sameAs Q425122.
- Epirubicin sameAs EPIRUBICIN.
- Epirubicin sameAs DB00445.
- Epirubicin sameAs Epirubicin.
- Epirubicin wasDerivedFrom Epirubicin?oldid=565990152.
- Epirubicin depiction Epirubicin.png.
- Epirubicin isPrimaryTopicOf Epirubicin.