Matches in DBpedia 2014 for { <http://dbpedia.org/resource/F-15,599> ?p ?o. }
Showing items 1 to 38 of
38
with 100 items per page.
- F-15,599 abstract "F-15,599 is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity (also known as "biased agonism") by strongly activating 5-HT1A receptors in the prefrontal cortex while having little effect on autoreceptors in the raphe nucleus. As a result, it has been touted as a preferential postsynaptic 5-HT1A receptor agonist and has been investigated as a novel potential antidepressant.In cognitive tests in rodent, F-15,599 attenuates memory deficits elicited by the NMDA receptor antagonist PCP, suggesting that it may improve cognitive function in disorders such as schizophrenia.A subsequent study showed that F-15,599 reduces breathing irregularity and apneas observed in mice with mutations of the MeCP2 gene. Dysruption of MeCP2 gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease.F-15,599 was discovered and developed by Pierre Fabre Médicament, a French pharmaceuticals company. In September 2013, F-15,599 was out-licensed to Neurolixis Inc, a California-based biotechnology company. Neurolixis announced that it intends to re-purpose F-15,599 for the treatment of Rett syndrome. and obtained Orphan Drug designation from the U.S. Food and Drug Administration (FDA) and from the European Commission for this indication.".
- F-15,599 iupacName "3-chloro-4-fluorophenyl-[4-fluoro-4-[[(5-methylpyrimidin-2-ylmethyl)amino]methyl]piperidin-1-yl]methanone".
- F-15,599 thumbnail F-15599-structure.png?width=300.
- F-15,599 wikiPageExternalLink www.neurolixis.com.
- F-15,599 wikiPageID "26612429".
- F-15,599 wikiPageRevisionID "598763634".
- F-15,599 c "19".
- F-15,599 chemspiderid "9916065".
- F-15,599 cl "1".
- F-15,599 f "2".
- F-15,599 h "22".
- F-15,599 hasPhotoCollection F-15,599.
- F-15,599 iupacName "3".
- F-15,599 legalStatus "Uncontrolled".
- F-15,599 molecularWeight "395.854".
- F-15,599 n "4".
- F-15,599 o "1".
- F-15,599 routesOfAdministration "Oral".
- F-15,599 smiles "Cc3cncCNCCCCN2Ccccc1F".
- F-15,599 verifiedfields "changed".
- F-15,599 verifiedrevid "451554460".
- F-15,599 watchedfields "changed".
- F-15,599 subject Category:Amides.
- F-15,599 subject Category:Amines.
- F-15,599 subject Category:Organochlorides.
- F-15,599 subject Category:Organofluorides.
- F-15,599 subject Category:Piperidines.
- F-15,599 subject Category:Pyrimidines.
- F-15,599 type Drug.
- F-15,599 type FunctionalSubstance.
- F-15,599 comment "F-15,599 is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity (also known as "biased agonism") by strongly activating 5-HT1A receptors in the prefrontal cortex while having little effect on autoreceptors in the raphe nucleus.".
- F-15,599 label "F-15,599".
- F-15,599 sameAs m.0bh7q49.
- F-15,599 sameAs Q5423588.
- F-15,599 sameAs Q5423588.
- F-15,599 wasDerivedFrom F-15,599?oldid=598763634.
- F-15,599 depiction F-15599-structure.png.
- F-15,599 isPrimaryTopicOf F-15,599.