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- FOLFIRINOX abstract "FOLFIRINOX is a chemotherapy regimen for treatment of advanced pancreatic cancer. It is made up of the following four drugs: FOL – folinic acid (leucovorin), a vitamin B derivative that modulates/potentiates/reduces the side effects of fluorouracil; F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops DNA synthesis; IRIN – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating; and OX – oxaliplatin (Eloxatin), a platinum-based antineoplastic agent, which inhibits DNA repair and/or DNA synthesis.The regimen emerged in 2010 as a new treatment for patients with metastatic pancreatic cancer. A 2011 study published in the New England Journal of Medicine found that FOLFIRINOX produced the longest improvement in survival ever seen in a phase III clinical trial of patients with advanced pancreatic cancer, with patients on the FOLFIRINOX treatment living approximately four months longer than patients receiving the standard gemcitabine treatment (11.1 months compared with 6.8 months). However, FOLFIRINOX is a potentially highly toxic combination of drugs with serious side effects, and thus only patients with good performance status are candidates for the regimen. In 2013, the U.S. Food and Drug Administration approved protein-bound paclitaxel (Abraxane) as a less toxic—albeit less effective—alternative to FOLFIRINOX for treating late-stage pancreatic cancer.".
- FOLFIRINOX wikiPageID "40466996".
- FOLFIRINOX wikiPageRevisionID "572116881".
- FOLFIRINOX subject Category:Chemotherapy_regimens.
- FOLFIRINOX comment "FOLFIRINOX is a chemotherapy regimen for treatment of advanced pancreatic cancer.".
- FOLFIRINOX label "FOLFIRINOX".
- FOLFIRINOX sameAs m.0wzs1mj.
- FOLFIRINOX sameAs Q17144959.
- FOLFIRINOX sameAs Q17144959.
- FOLFIRINOX wasDerivedFrom FOLFIRINOX?oldid=572116881.
- FOLFIRINOX isPrimaryTopicOf FOLFIRINOX.