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- FXYD_family abstract "The FXYD protein family is a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the amino acid sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator.It contains at least seven members in mammals. Two other family members that are not obvious orthologs of any identified mammalian FXYD protein exist in zebrafish. All these proteins share a signature sequence of six conserved amino acids comprising the FXYD motif in the NH2-terminus, and two glycines andone serine residue in the transmembrane domain. FXYD proteins are widely distributed in mammalian tissues with prominent expression in tissues that perform fluid and solute transport or that are electrically excitable.Initial functional characterization suggested that FXYD proteins act as channels or as modulators of ion channels. However, studies have revealed that most FXYD proteins have another specific function and act as tissue-specificregulatory subunits of the Na,K-ATPase. Each of these auxiliary subunits produces a distinct functional effect on the transport characteristics of the Na,K-ATPase that is adjusted to the specific functional demands of the tissue in which the FXYD protein is expressed. FXYD proteins appear to preferentially associate with Na,K-ATPase alpha1-beta isozymes, and affect their function in a way that render them operationally complementary or supplementary to coexisting isozymes.".
- FXYD_family symbol "ATP1G1_PLM_MAT8".
- FXYD_family thumbnail PDB_2jo1_EBI.png?width=300.
- FXYD_family wikiPageID "24555400".
- FXYD_family wikiPageRevisionID "591381992".
- FXYD_family caption "Structure of Na,K-ATPase regulatory protein FXYD1.".
- FXYD_family hasPhotoCollection FXYD_family.
- FXYD_family interpro "IPR000272".
- FXYD_family name "ATP1G1/PLM/MAT8 family".
- FXYD_family opmFamily "70".
- FXYD_family opmProtein "2".
- FXYD_family pfam "PF02038".
- FXYD_family prosite "PS01310".
- FXYD_family symbol "ATP1G1_PLM_MAT8".
- FXYD_family tcdb "1".
- FXYD_family subject Category:Protein_domains.
- FXYD_family subject Category:Protein_families.
- FXYD_family subject Category:Single-pass_transmembrane_proteins.
- FXYD_family type Abstraction100002137.
- FXYD_family type Attribute100024264.
- FXYD_family type Chemical114806838.
- FXYD_family type Compound114818238.
- FXYD_family type Environment113934596.
- FXYD_family type Macromolecule114944888.
- FXYD_family type Material114580897.
- FXYD_family type Matter100020827.
- FXYD_family type Molecule114682133.
- FXYD_family type OrganicCompound114727670.
- FXYD_family type Part113809207.
- FXYD_family type PhysicalEntity100001930.
- FXYD_family type Protein114728724.
- FXYD_family type ProteinDomains.
- FXYD_family type Relation100031921.
- FXYD_family type Single-passTransmembraneProteins.
- FXYD_family type Situation113927383.
- FXYD_family type Sphere114514039.
- FXYD_family type State100024720.
- FXYD_family type Substance100019613.
- FXYD_family type Thing100002452.
- FXYD_family type Unit109465459.
- FXYD_family type Biomolecule.
- FXYD_family type Protein.
- FXYD_family type BiologicalObject.
- FXYD_family comment "The FXYD protein family is a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the amino acid sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator.It contains at least seven members in mammals. Two other family members that are not obvious orthologs of any identified mammalian FXYD protein exist in zebrafish.".
- FXYD_family label "FXYD family".
- FXYD_family sameAs m.080662h.
- FXYD_family sameAs Q5427396.
- FXYD_family sameAs Q5427396.
- FXYD_family sameAs FXYD_family.
- FXYD_family wasDerivedFrom FXYD_family?oldid=591381992.
- FXYD_family depiction PDB_2jo1_EBI.png.
- FXYD_family isPrimaryTopicOf FXYD_family.