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- Fascin abstract "Fascin is an actin cross-linking protein.It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins. It is calcium insensitive and monomeric.Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Fascin localizes to actin-rich protrusions at the cell surface called filopodia. Recent study shows that fascin also localizes to invadopodia, membrane protrusions formed at the adherent cell surface that facilitate extracellular matrix (ECM) invasion, this provide a potential molecular mechanism for how fascin increases the invasiveness of cancer cells since fascin expression is upregulated in a spectrum of cancers.Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer. It is also helpful in identifying Hodgkin cells.".
- Fascin arm "p".
- Fascin arm "q".
- Fascin band "22".
- Fascin band "25".
- Fascin band "31.3".
- Fascin chromosome "17".
- Fascin chromosome "7".
- Fascin entrezgene "25794".
- Fascin entrezgene "29999".
- Fascin entrezgene "6624".
- Fascin hgncid "11148".
- Fascin hgncid "3960".
- Fascin hgncid "3961".
- Fascin omim "602689".
- Fascin omim "607643".
- Fascin refseq "NM_003088".
- Fascin refseq "NM_012418".
- Fascin refseq "NM_020369".
- Fascin symbol "FSCN1".
- Fascin symbol "FSCN2".
- Fascin symbol "FSCN3".
- Fascin symbol "SNL".
- Fascin thumbnail Fascin.pdb.png?width=300.
- Fascin uniprot "O14926".
- Fascin uniprot "Q16658".
- Fascin uniprot "Q9NQT6".
- Fascin wikiPageID "10240143".
- Fascin wikiPageRevisionID "603899629".
- Fascin altsymbols "SNL".
- Fascin arm "p".
- Fascin arm "q".
- Fascin band "22".
- Fascin band "25".
- Fascin band "31.3".
- Fascin caption "Crystallographic structure of dimeric human fascin 1.".
- Fascin chromosome "17".
- Fascin chromosome "7".
- Fascin entrezgene "25794".
- Fascin entrezgene "29999".
- Fascin entrezgene "6624".
- Fascin hasPhotoCollection Fascin.
- Fascin hgncid "11148".
- Fascin hgncid "3960".
- Fascin hgncid "3961".
- Fascin name FSCN1.
- Fascin name FSCN2.
- Fascin name FSCN3.
- Fascin omim "602689".
- Fascin omim "607643".
- Fascin refseq "NM_003088".
- Fascin refseq "NM_012418".
- Fascin refseq "NM_020369".
- Fascin symbol FSCN1.
- Fascin symbol FSCN2.
- Fascin symbol FSCN3.
- Fascin uniprot "O14926".
- Fascin uniprot "Q16658".
- Fascin uniprot "Q9NQT6".
- Fascin subject Category:Proteins.
- Fascin type Abstraction100002137.
- Fascin type Chemical114806838.
- Fascin type Compound114818238.
- Fascin type Macromolecule114944888.
- Fascin type Material114580897.
- Fascin type Matter100020827.
- Fascin type Molecule114682133.
- Fascin type OrganicCompound114727670.
- Fascin type Part113809207.
- Fascin type PhysicalEntity100001930.
- Fascin type Protein114728724.
- Fascin type Proteins.
- Fascin type Relation100031921.
- Fascin type Substance100019613.
- Fascin type Thing100002452.
- Fascin type Unit109465459.
- Fascin type Biomolecule.
- Fascin type Protein.
- Fascin type BiologicalObject.
- Fascin comment "Fascin is an actin cross-linking protein.It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin (from the Latin for bundle) is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins.".
- Fascin label "Fascin".
- Fascin sameAs m.02q677d.
- Fascin sameAs Q5436645.
- Fascin sameAs Q5436645.
- Fascin sameAs Fascin.
- Fascin wasDerivedFrom Fascin?oldid=603899629.
- Fascin depiction Fascin.pdb.png.
- Fascin isPrimaryTopicOf Fascin.
- Fascin name "fascin homolog 1".
- Fascin name "fascin homolog 3, testicular".
- Fascin name "fascin homolog, retinal".