Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Fenobam> ?p ?o. }
Showing items 1 to 49 of
49
with 100 items per page.
- Fenobam abstract "Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it has been used as a lead compound for the development of a range of newer mGluR5 antagonists.Fenobam has anxiolytic effects comparable to those of benzodiazepine drugs, but was never commercially marketed for the treatment of anxiety due to dose-limiting side effects such as amnesia and psychotomimetic symptoms. Following the discovery of its activity as a potent negative allosteric modulator of mGluR5, fenobam has been re-investigated for many applications, with its profile of combined antidepressant, anxiolytic, analgesic and anti-addictive effects potentially useful given the common co-morbidity of these symptoms. It has also shown promising initial results in the treatment of fragile X syndrome. It was developed by a team at McNeil Laboratories in the 1970s.".
- Fenobam fdaUniiCode "078RCY7I27".
- Fenobam iupacName "1-(3-chlorophenyl)-3-(3-methyl-5-oxo-4H-imidazol-2-yl)urea".
- Fenobam thumbnail Fenobam.svg?width=300.
- Fenobam wikiPageID "9552884".
- Fenobam wikiPageRevisionID "600786002".
- Fenobam hasPhotoCollection Fenobam.
- Fenobam imagefile "Fenobam.svg".
- Fenobam imagesize "200".
- Fenobam iupacname "1".
- Fenobam unii "78".
- Fenobam verifiedfields "changed".
- Fenobam verifiedrevid "375069552".
- Fenobam watchedfields "changed".
- Fenobam subject Category:Anxiolytics.
- Fenobam subject Category:Imidazolines.
- Fenobam subject Category:Lactams.
- Fenobam subject Category:Organochlorides.
- Fenobam subject Category:Orphan_drugs.
- Fenobam subject Category:Ureas.
- Fenobam type Agent114778436.
- Fenobam type Anxiolytics.
- Fenobam type CausalAgent100007347.
- Fenobam type Drug103247620.
- Fenobam type DrugOfAbuse103248958.
- Fenobam type Matter100020827.
- Fenobam type Medicine103740161.
- Fenobam type MinorTranquilizer103771443.
- Fenobam type OrphanDrugs.
- Fenobam type PhysicalEntity100001930.
- Fenobam type PsychotropicAgent104017429.
- Fenobam type Sedative-hypnotic104166841.
- Fenobam type Sedative104166553.
- Fenobam type Substance100020090.
- Fenobam type Tranquilizer104470232.
- Fenobam type ChemicalCompound.
- Fenobam type ChemicalSubstance.
- Fenobam type ChemicalSubstanceType.
- Fenobam type ChemicalObject.
- Fenobam type Thing.
- Fenobam comment "Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain.".
- Fenobam label "Fenobam".
- Fenobam sameAs m.02pjqj3.
- Fenobam sameAs Q5443558.
- Fenobam sameAs Q5443558.
- Fenobam sameAs Fenobam.
- Fenobam wasDerivedFrom Fenobam?oldid=600786002.
- Fenobam depiction Fenobam.svg.
- Fenobam isPrimaryTopicOf Fenobam.