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- Fialuridine abstract "Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue. It was originally designed as a therapy for hepatitis B virus infection. In a 1992 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from fulminant liver failure associated with lactic acidosis. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug induced mitochondrial damage, as hinted by in-vitro studies.A study published by researchers from the Liver Disease Research Branch at the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland using chimeric immunodeficient mice with human-origin liver revealed that fialuridine is in fact toxic to human liver cells. 'Humanized' Mouse Detects Deadly Drug Side Effects".
- Fialuridine atcPrefix "none".
- Fialuridine fdaUniiCode "53T7IN77LC".
- Fialuridine iupacName "1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)- 2-tetrahydrofuranyl]-5-iodopyrimidine-2,4-dione".
- Fialuridine pubchem "50313".
- Fialuridine thumbnail Fialuridine.png?width=300.
- Fialuridine wikiPageExternalLink openbook.php?record_id=4887&page=R1.
- Fialuridine wikiPageID "16738992".
- Fialuridine wikiPageRevisionID "606334037".
- Fialuridine alt "Ball-and-stick model".
- Fialuridine alt "Skeletal formula".
- Fialuridine atcPrefix "none".
- Fialuridine c "9".
- Fialuridine chembl "271475".
- Fialuridine f "1".
- Fialuridine h "10".
- Fialuridine hasPhotoCollection Fialuridine.
- Fialuridine i "1".
- Fialuridine image "Fialuridine-3D-balls.png".
- Fialuridine iupacName "1".
- Fialuridine kegg "D04181".
- Fialuridine molecularWeight "372.09".
- Fialuridine n "2".
- Fialuridine niaidChemdb "70971".
- Fialuridine o "5".
- Fialuridine pubchem "50313".
- Fialuridine synonyms "2".
- Fialuridine unii "53".
- Fialuridine verifiedfields "changed".
- Fialuridine verifiedrevid "443996139".
- Fialuridine watchedfields "changed".
- Fialuridine subject Category:Alcohols.
- Fialuridine subject Category:Antivirals.
- Fialuridine subject Category:Lactams.
- Fialuridine subject Category:Nucleosides.
- Fialuridine subject Category:Organofluorides.
- Fialuridine subject Category:Organoiodides.
- Fialuridine subject Category:Pyrimidinediones.
- Fialuridine subject Category:Tetrahydrofurans.
- Fialuridine subject Category:Ureas.
- Fialuridine type Abstraction100002137.
- Fialuridine type Agent114778436.
- Fialuridine type Alcohol107884567.
- Fialuridine type Alcohols.
- Fialuridine type Beverage107881800.
- Fialuridine type CausalAgent100007347.
- Fialuridine type Chemical114806838.
- Fialuridine type Compound114818238.
- Fialuridine type Drug103247620.
- Fialuridine type DrugOfAbuse103248958.
- Fialuridine type Fluid114939900.
- Fialuridine type Food100021265.
- Fialuridine type Glycoside114887305.
- Fialuridine type Liquid114940386.
- Fialuridine type Material114580897.
- Fialuridine type Matter100020827.
- Fialuridine type Nucleoside114964367.
- Fialuridine type Nucleosides.
- Fialuridine type OrganicCompound114727670.
- Fialuridine type Part113809207.
- Fialuridine type PhysicalEntity100001930.
- Fialuridine type Relation100031921.
- Fialuridine type Substance100019613.
- Fialuridine type Substance100020090.
- Fialuridine type Urea115085472.
- Fialuridine type Ureas.
- Fialuridine type Drug.
- Fialuridine type DrugProduct.
- Fialuridine type FunctionalSubstance.
- Fialuridine comment "Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue. It was originally designed as a therapy for hepatitis B virus infection. In a 1992 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from fulminant liver failure associated with lactic acidosis. This toxicity was unusual in that it was not predicted by animal studies.".
- Fialuridine label "Fialuridine".
- Fialuridine sameAs m.0404mmg.
- Fialuridine sameAs Q5446286.
- Fialuridine sameAs Q5446286.
- Fialuridine sameAs Fialuridine.
- Fialuridine wasDerivedFrom Fialuridine?oldid=606334037.
- Fialuridine depiction Fialuridine.png.
- Fialuridine isPrimaryTopicOf Fialuridine.
