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- Fibulin abstract "Fibulin (FY-beau-lin) (now known as Fibulin-1 FBLN1) is the prototypic member of a multigene family, currently with seven members. Fibulin-1 is a calcium-binding glycoprotein. In vertebrates, fibulin-1 is found in blood and extracellular matrices. In the extracellular matrix, fibulin-1 associates with basement membranes and elastic fibers. The association with these matrix structures is mediated by its ability to interact with numerous extracellular matrix constituents including fibronectin, proteoglycans, laminins and tropoelastin. In blood, fibulin-1 binds to fibrinogen and incorporates into clots. Fibulins are secreted glycoproteins that become incorporated into a fibrillar extracellular matrix when expressed by cultured cells or added exogenously to cell monolayers. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. The amino-terminal domain I of fibulin consists of three anaphylatoxin-like (AT) modules, each approximately 40 residues long and containing four or six cysteines. The structure of an AT module was determined for the complement-derived anaphylatoxin C3a, and was found to be a compact alpha-helical fold that is stabilized by three disulphide bridges in the pattern Cys14, Cys25 and Cys36 (where Cys is cysteine). The bulk of the remaining portion of the fibulin molecule is a series of nine EGF-like repeats.".
- Fibulin symbol "ANATO".
- Fibulin thumbnail PDB_1c5a_EBI.jpg?width=300.
- Fibulin wikiPageID "11648371".
- Fibulin wikiPageRevisionID "591307666".
- Fibulin caption "Structure of porcine C5adesArg.".
- Fibulin hasPhotoCollection Fibulin.
- Fibulin interpro "IPR000020".
- Fibulin name "Anaphylotoxin-like domain".
- Fibulin pdb "B:693-728 :21-55 A:698-732 :698-732".
- Fibulin pfam "PF01821".
- Fibulin prosite "PDOC00906".
- Fibulin scop "1".
- Fibulin smart "ANATO".
- Fibulin symbol "ANATO".
- Fibulin subject Category:Blood_proteins.
- Fibulin subject Category:Protein_domains.
- Fibulin type Abstraction100002137.
- Fibulin type Attribute100024264.
- Fibulin type BloodProteins.
- Fibulin type Chemical114806838.
- Fibulin type Compound114818238.
- Fibulin type Environment113934596.
- Fibulin type Macromolecule114944888.
- Fibulin type Material114580897.
- Fibulin type Matter100020827.
- Fibulin type Molecule114682133.
- Fibulin type OrganicCompound114727670.
- Fibulin type Part113809207.
- Fibulin type PhysicalEntity100001930.
- Fibulin type Protein114728724.
- Fibulin type ProteinDomains.
- Fibulin type Relation100031921.
- Fibulin type Situation113927383.
- Fibulin type Sphere114514039.
- Fibulin type State100024720.
- Fibulin type Substance100019613.
- Fibulin type Thing100002452.
- Fibulin type Unit109465459.
- Fibulin type Biomolecule.
- Fibulin type Protein.
- Fibulin type BiologicalObject.
- Fibulin comment "Fibulin (FY-beau-lin) (now known as Fibulin-1 FBLN1) is the prototypic member of a multigene family, currently with seven members. Fibulin-1 is a calcium-binding glycoprotein. In vertebrates, fibulin-1 is found in blood and extracellular matrices. In the extracellular matrix, fibulin-1 associates with basement membranes and elastic fibers.".
- Fibulin label "Fibulin".
- Fibulin sameAs m.02rmnsw.
- Fibulin sameAs Q5446488.
- Fibulin sameAs Q5446488.
- Fibulin sameAs Fibulin.
- Fibulin wasDerivedFrom Fibulin?oldid=591307666.
- Fibulin depiction PDB_1c5a_EBI.jpg.
- Fibulin isPrimaryTopicOf Fibulin.