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- Follicular_B_cell abstract "Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary lymphoid organs, including spleen and lymph nodes. Mature B cells from the spleen can be divided into two main populations: FO B cells, which constitute the majority, and marginal zone B-cells, lining outside the marginal sinus and bordering the red pulp. FO B cells express high levels of IgM, IgD, and CD23; lower levels of CD21; and no CD1 or CD5, readily distinguishing this compartment from B1 B cells and marginal zone B-cells . FO B cells organize into the primary follicles of B cell zones focused around follicular dendritic cells in the white pulp of the spleen and the cortical areas of peripheral lymph nodes. Multiphoton-based live imaging of lymph nodes indicate continuous movement of FO B cells within these follicular areas at velocities of ~6 µm per min. Recent studies indicate movement along the processes of FDC as a guidance system for mature resting B cells in peripheral lymph nodes. Unlike their MZ counterpart, FO B cells freely recirculate, comprising >95% of the B cells in peripheral lymph nodes.The BCR repertoire of the follicular B cell compartment also appears under positive selection pressures during final maturation in the spleen. However, diversity is substantially broader than B1 B and MZ B cell compartments. More importantly, FO B cells require CD40-CD40L dependent T cell help to promote effective primary immune responses and antibody isotype switch and to establish high-affinity B cell memory.".
- Follicular_B_cell wikiPageID "19603289".
- Follicular_B_cell wikiPageRevisionID "533772214".
- Follicular_B_cell hasPhotoCollection Follicular_B_cell.
- Follicular_B_cell subject Category:Lymphocytes.
- Follicular_B_cell type BloodCell105449268.
- Follicular_B_cell type Cell100006484.
- Follicular_B_cell type FreePhagocyte105451265.
- Follicular_B_cell type Leukocyte105449959.
- Follicular_B_cell type LivingThing100004258.
- Follicular_B_cell type Lymphocyte105451384.
- Follicular_B_cell type Lymphocytes.
- Follicular_B_cell type Object100002684.
- Follicular_B_cell type Phagocyte105450888.
- Follicular_B_cell type PhysicalEntity100001930.
- Follicular_B_cell type SomaticCell105430628.
- Follicular_B_cell type Whole100003553.
- Follicular_B_cell comment "Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary lymphoid organs, including spleen and lymph nodes. Mature B cells from the spleen can be divided into two main populations: FO B cells, which constitute the majority, and marginal zone B-cells, lining outside the marginal sinus and bordering the red pulp.".
- Follicular_B_cell label "Follicular B cell".
- Follicular_B_cell sameAs m.04n2trj.
- Follicular_B_cell sameAs Q5464649.
- Follicular_B_cell sameAs Q5464649.
- Follicular_B_cell sameAs Follicular_B_cell.
- Follicular_B_cell wasDerivedFrom Follicular_B_cell?oldid=533772214.
- Follicular_B_cell isPrimaryTopicOf Follicular_B_cell.