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- Formate–tetrahydrofolate_ligase abstract "In enzymology, a formate-tetrahydrofolate ligase (EC 6.3.4.3) is an enzyme that catalyzes the chemical reactionATP + formate + tetrahydrofolate ADP + phosphate + 10-formyltetrahydrofolateThe 3 substrates of this enzyme are ATP, formate, and tetrahydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyltetrahydrofolate.This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate. In eukaryotes the FTHFS activity is expressed by a multifunctional enzyme, C-1-tetrahydrofolate synthase (C1-THF synthase), which also catalyses the dehydrogenase and cyclohydrolase activities. Two forms of C1-THF synthases are known, one is located in the mitochondrial matrix, while the second one is cytoplasmic. In both forms the FTHFS domain consists of about 600 amino acid residues and is located in the C-terminal section of C1-THF synthase. In prokaryotes FTHFS activity is expressed by a monofunctional homotetrameric enzyme of about 560 amino acid residues.".
- Formate–tetrahydrofolate_ligase thumbnail PDB_1eg7_EBI.jpg?width=300.
- Formate–tetrahydrofolate_ligase wikiPageID "14285885".
- Formate–tetrahydrofolate_ligase wikiPageRevisionID "591348499".
- Formate–tetrahydrofolate_ligase caption "the crystal structure of formyltetrahydrofolate synthetase from moorella thermoacetica".
- Formate–tetrahydrofolate_ligase casNumber "9023".
- Formate–tetrahydrofolate_ligase ecNumber "6.3".
- Formate–tetrahydrofolate_ligase goCode "4329".
- Formate–tetrahydrofolate_ligase interpro "IPR000559".
- Formate–tetrahydrofolate_ligase iubmbEcNumber "6".
- Formate–tetrahydrofolate_ligase name "Formate--tetrahydrofolate ligase".
- Formate–tetrahydrofolate_ligase name "formate-tetrahydrofolate ligase".
- Formate–tetrahydrofolate_ligase pfam "PF01268".
- Formate–tetrahydrofolate_ligase pfamClan "CL0023".
- Formate–tetrahydrofolate_ligase prosite "PDOC00595".
- Formate–tetrahydrofolate_ligase scop "1".
- Formate–tetrahydrofolate_ligase symbol "FTHFS".
- Formate–tetrahydrofolate_ligase subject Category:EC_6.3.4.
- Formate–tetrahydrofolate_ligase subject Category:Enzymes_of_known_structure.
- Formate–tetrahydrofolate_ligase subject Category:Protein_families.
- Formate–tetrahydrofolate_ligase type Biomolecule.
- Formate–tetrahydrofolate_ligase type Enzyme.
- Formate–tetrahydrofolate_ligase type BiologicalObject.
- Formate–tetrahydrofolate_ligase comment "In enzymology, a formate-tetrahydrofolate ligase (EC 6.3.4.3) is an enzyme that catalyzes the chemical reactionATP + formate + tetrahydrofolate ADP + phosphate + 10-formyltetrahydrofolateThe 3 substrates of this enzyme are ATP, formate, and tetrahydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyltetrahydrofolate.This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.".
- Formate–tetrahydrofolate_ligase label "Formate–tetrahydrofolate ligase".
- Formate–tetrahydrofolate_ligase label "Formiate-tétrahydrofolate ligase".
- Formate–tetrahydrofolate_ligase sameAs Formate%E2%80%93tetrahydrofolate_ligase.
- Formate–tetrahydrofolate_ligase sameAs Formiate-tétrahydrofolate_ligase.
- Formate–tetrahydrofolate_ligase sameAs Q5470024.
- Formate–tetrahydrofolate_ligase sameAs Q5470024.
- Formate–tetrahydrofolate_ligase wasDerivedFrom Formate–tetrahydrofolate_ligase?oldid=591348499.
- Formate–tetrahydrofolate_ligase depiction PDB_1eg7_EBI.jpg.