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- Formylglycine-generating_sulfatase_enzyme abstract "In molecular biology, formylglycine-generating sulfatase enzyme is a protein domain which has a structure homologous to the complex alpha/beta topology found in sulfatase-modifying factors (SUMF1). SUMF1 is a paralogue of oxoalanine-generating enzyme, also called C(alpha)-formylglycine generating enzyme (FGE). SUMF1 converts newly synthesized inactive sulfatases to their active form by modifying an active site cysteine residue to oxoalanine. Sulfatases are essential for the degradation of sulfate esters, whose catalytic activity is dependent upon an oxoalanine residue. Defects in SUMF1 or FGE cause multiple sulfatase deficiency (MSD), which leads to the impairment of all sulfatases and to the accumulation of glycoaminoglycans or sulfolipids, causing early infant death. Known substrates for SUMF1 are: N-acetylgalactosamine-6-sulfate sulfatase (GALNS), arylsulfatase A (ARSA), steroid sulfatase (STS) and arylsulfatase E (ARSE). SUMF1 occurs in the endoplasmic reticulum or its lumen.".
- Formylglycine-generating_sulfatase_enzyme symbol "FGE-sulfatase".
- Formylglycine-generating_sulfatase_enzyme thumbnail PDB_2aik_EBI.jpg?width=300.
- Formylglycine-generating_sulfatase_enzyme wikiPageID "32753683".
- Formylglycine-generating_sulfatase_enzyme wikiPageRevisionID "591349295".
- Formylglycine-generating_sulfatase_enzyme caption "336.0".
- Formylglycine-generating_sulfatase_enzyme hasPhotoCollection Formylglycine-generating_sulfatase_enzyme.
- Formylglycine-generating_sulfatase_enzyme interpro "IPR005532".
- Formylglycine-generating_sulfatase_enzyme name "Formylglycine-generating sulfatase enzyme".
- Formylglycine-generating_sulfatase_enzyme pfam "PF03781".
- Formylglycine-generating_sulfatase_enzyme symbol "FGE-sulfatase".
- Formylglycine-generating_sulfatase_enzyme subject Category:Protein_domains.
- Formylglycine-generating_sulfatase_enzyme type Abstraction100002137.
- Formylglycine-generating_sulfatase_enzyme type Attribute100024264.
- Formylglycine-generating_sulfatase_enzyme type Environment113934596.
- Formylglycine-generating_sulfatase_enzyme type ProteinDomains.
- Formylglycine-generating_sulfatase_enzyme type Situation113927383.
- Formylglycine-generating_sulfatase_enzyme type Sphere114514039.
- Formylglycine-generating_sulfatase_enzyme type State100024720.
- Formylglycine-generating_sulfatase_enzyme type Biomolecule.
- Formylglycine-generating_sulfatase_enzyme type Protein.
- Formylglycine-generating_sulfatase_enzyme type BiologicalObject.
- Formylglycine-generating_sulfatase_enzyme comment "In molecular biology, formylglycine-generating sulfatase enzyme is a protein domain which has a structure homologous to the complex alpha/beta topology found in sulfatase-modifying factors (SUMF1). SUMF1 is a paralogue of oxoalanine-generating enzyme, also called C(alpha)-formylglycine generating enzyme (FGE). SUMF1 converts newly synthesized inactive sulfatases to their active form by modifying an active site cysteine residue to oxoalanine.".
- Formylglycine-generating_sulfatase_enzyme label "Formylglycine-generating sulfatase enzyme".
- Formylglycine-generating_sulfatase_enzyme sameAs m.0h3v5rh.
- Formylglycine-generating_sulfatase_enzyme sameAs Q5470360.
- Formylglycine-generating_sulfatase_enzyme sameAs Q5470360.
- Formylglycine-generating_sulfatase_enzyme sameAs Formylglycine-generating_sulfatase_enzyme.
- Formylglycine-generating_sulfatase_enzyme wasDerivedFrom Formylglycine-generating_sulfatase_enzyme?oldid=591349295.
- Formylglycine-generating_sulfatase_enzyme depiction PDB_2aik_EBI.jpg.
- Formylglycine-generating_sulfatase_enzyme isPrimaryTopicOf Formylglycine-generating_sulfatase_enzyme.