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- Fosazepam abstract "Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble salt of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water.Fosazepam has similar effects on sleep as other benzodiazepines. In a clinical trial it was reported that fosazepam to lead to increased sleep duration with less broken sleep but sleep quality was worsened with suppressed deep sleep and increased light sleep. Adverse effects included feelings of impaired morning vitality and upon discontinuing the drug benzodiazepine withdrawal symptoms of anxiety, impaired concentration and impaired morning vitality were experienced. Another clinical trial also found worsening of sleep while on benzodiazepines as well as during withdrawal with suppression of deep sleep stages including REM sleep, with increased light sleep upon withdrawal. The main metabolites of fosazepam are 3-hydroxyfosazepam and the active metabolite desmethyldiazepam which has a very long elimination half-life of about 3 days. Tolerance to the hypnotic effects of fosazepam starts to develop after about 7 days of use. Due to the very long elimination half-life of the active metabolite of fosazepam it is not recommended for use as a hypnotic. The main pharmacological effects of fosazepam may be due to its metabolite nordiazepam (desmethyldiazepam), rather than the parent drug. The long-acting active metabolite nordazepam can cause extended sedative effects at high doses or with prolonged use, and may produce residual sedation upon awakening.Fosazepam is of relatively low potency compared to other benzodiazepine derivatives, with a 100 mg dose of fosazepam equivalent to 10 mg of nitrazepam. 60 mg of fosazepam has also been estimated to be equivalent to about 5 – 10 mg of diazepam. Fosazepam has similar effects to nitrazepam, but with a shorter duration of action and less tendency to cause over sedation, motor-impairment, amnesia, rebound insomnia, and morning grogginess.".
- Fosazepam atcPrefix "none".
- Fosazepam casNumber "35322-07-7".
- Fosazepam fdaUniiCode "13AK3H33SG".
- Fosazepam iupacName "7-chloro-1-(dimethylphosphorylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one".
- Fosazepam pubchem "37114".
- Fosazepam thumbnail Fosazepam.svg?width=300.
- Fosazepam wikiPageID "13365521".
- Fosazepam wikiPageRevisionID "591353199".
- Fosazepam atcPrefix "none".
- Fosazepam c "18".
- Fosazepam casNumber "35322".
- Fosazepam chemspiderid "34056".
- Fosazepam cl "1".
- Fosazepam h "18".
- Fosazepam hasPhotoCollection Fosazepam.
- Fosazepam inchi "1".
- Fosazepam inchikey "JMYCGCXYZZHWMO-UHFFFAOYAG".
- Fosazepam iupacName "7".
- Fosazepam kegg "D04248".
- Fosazepam molecularWeight "360.774".
- Fosazepam n "2".
- Fosazepam o "2".
- Fosazepam p "1".
- Fosazepam pubchem "37114".
- Fosazepam smiles "ClC1=CC2=CNC=O".
- Fosazepam stdinchi "1".
- Fosazepam stdinchikey "JMYCGCXYZZHWMO-UHFFFAOYSA-N".
- Fosazepam unii "13".
- Fosazepam verifiedrevid "455325548".
- Fosazepam watchedfields "changed".
- Fosazepam width "180".
- Fosazepam subject Category:Benzodiazepines.
- Fosazepam subject Category:Lactams.
- Fosazepam subject Category:Organochlorides.
- Fosazepam type Agent114778436.
- Fosazepam type Benzodiazepine102830852.
- Fosazepam type Benzodiazepines.
- Fosazepam type CausalAgent100007347.
- Fosazepam type Drug103247620.
- Fosazepam type DrugOfAbuse103248958.
- Fosazepam type Matter100020827.
- Fosazepam type Medicine103740161.
- Fosazepam type MinorTranquilizer103771443.
- Fosazepam type MuscleRelaxant103800001.
- Fosazepam type PhysicalEntity100001930.
- Fosazepam type PsychotropicAgent104017429.
- Fosazepam type Relaxant104072811.
- Fosazepam type Sedative-hypnotic104166841.
- Fosazepam type Sedative104166553.
- Fosazepam type Substance100020090.
- Fosazepam type Tranquilizer104470232.
- Fosazepam type Drug.
- Fosazepam type DrugProduct.
- Fosazepam type FunctionalSubstance.
- Fosazepam comment "Fosazepam is a drug which is a benzodiazepine derivative; it is a water soluble salt of diazepam. It has sedative and anxiolytic effects, and is a derivative of diazepam which has been substituted with a dimethylphosphoryl group to improve solubility in water.Fosazepam has similar effects on sleep as other benzodiazepines.".
- Fosazepam label "Fosazepam".
- Fosazepam sameAs m.03c30dz.
- Fosazepam sameAs Q5473321.
- Fosazepam sameAs Q5473321.
- Fosazepam sameAs Fosazepam.
- Fosazepam wasDerivedFrom Fosazepam?oldid=591353199.
- Fosazepam depiction Fosazepam.svg.
- Fosazepam isPrimaryTopicOf Fosazepam.