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- Frakefamide abstract "Frakefamide (INN) is a synthetic, fluorinated opioid tetrapeptide with the amino acid sequence Tyr-D-Ala-(p-F)Phe-Phe-NH2 which acts as a peripherally-specific, selective μ-opioid receptor agonist. Despite its inability to penetrate the blood-brain-barrier and enter the central nervous system, frakefamide has potent analgesic effects and, unlike centrally-acting opioids like morphine, does not produce respiratory depression, indicating that its antinociceptive effects are mediated by peripheral μ-opioid receptors. It was under development for the treatment of pain by AstraZeneca and Shire but was shelved after phase II clinical trials.".
- Frakefamide atcPrefix "None".
- Frakefamide casNumber "188196-22-7".
- Frakefamide iupacName "4-fluoro-(L)-phenylalanyl-N-[(2R)-2-((L)-tyrosylamino)propanoyl]-(L)-phenylalaninamide".
- Frakefamide pubchem "5493563".
- Frakefamide thumbnail Frakefamide.svg?width=300.
- Frakefamide wikiPageID "35637659".
- Frakefamide wikiPageRevisionID "599129558".
- Frakefamide atcPrefix "None".
- Frakefamide c "30".
- Frakefamide casNumber "188196".
- Frakefamide chemspiderid "4591495".
- Frakefamide f "1".
- Frakefamide h "34".
- Frakefamide hasPhotoCollection Frakefamide.
- Frakefamide inchi "1".
- Frakefamide inchikey "HESSKXOHGGYIFY-JTQLPTLWBI".
- Frakefamide iupacName "4".
- Frakefamide molecularWeight "563.62".
- Frakefamide n "5".
- Frakefamide o "5".
- Frakefamide pubchem "5493563".
- Frakefamide smiles "Fc1cccC[C@H]CN[C@H]Cc3ccccc3".
- Frakefamide stdinchi "1".
- Frakefamide stdinchikey "HESSKXOHGGYIFY-JTQLPTLWSA-N".
- Frakefamide subject Category:Amides.
- Frakefamide subject Category:Analgesics.
- Frakefamide subject Category:Opioid_peptides.
- Frakefamide subject Category:Organofluorides.
- Frakefamide type Abstraction100002137.
- Frakefamide type Amide114724264.
- Frakefamide type Amides.
- Frakefamide type Chemical114806838.
- Frakefamide type Compound114818238.
- Frakefamide type Material114580897.
- Frakefamide type Matter100020827.
- Frakefamide type OrganicCompound114727670.
- Frakefamide type Part113809207.
- Frakefamide type Peptide114743046.
- Frakefamide type Peptides.
- Frakefamide type PhysicalEntity100001930.
- Frakefamide type Relation100031921.
- Frakefamide type Substance100019613.
- Frakefamide type Drug.
- Frakefamide type FunctionalSubstance.
- Frakefamide comment "Frakefamide (INN) is a synthetic, fluorinated opioid tetrapeptide with the amino acid sequence Tyr-D-Ala-(p-F)Phe-Phe-NH2 which acts as a peripherally-specific, selective μ-opioid receptor agonist.".
- Frakefamide label "Frakefamide".
- Frakefamide sameAs m.0jkvqtx.
- Frakefamide sameAs Q5477806.
- Frakefamide sameAs Q5477806.
- Frakefamide sameAs Frakefamide.
- Frakefamide wasDerivedFrom Frakefamide?oldid=599129558.
- Frakefamide depiction Frakefamide.svg.
- Frakefamide isPrimaryTopicOf Frakefamide.