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• Fructose_1,6-bisphosphatase abstract "Fructose bisphosphatase (EC 3.1.3.11) is an enzyme that converts fructose-1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis and the Calvin cycle which are both anabolic pathways. Fructose bisphosphatase catalyses the reverse of the reaction which is catalysed by phosphofructokinase in glycolysis. These enzymes only catalyse the reaction in one direction each, and are regulated by metabolites such as fructose 2,6-bisphosphate so that high activity of one of the two enzymes is accompanied by low activity of the other. More specifically, fructose 2,6-bisphosphate allosterically inhibits fructose 1,6-bisphosphatase, but activates phosphofructokinase-I. Fructose 1,6-bisphosphatase is involved in many different metabolic pathways and found in most organisms. FBPase requires metal ions for catalysis (Mg2+ and Mn2+ being preferred) and the enzyme is potently inhibited by Li+.The fold of fructose-1,6-bisphosphatase from pig was noted to be identical to that of inositol-1-phosphatase (IMPase). Inositol polyphosphate 1-phosphatase (IPPase), IMPase and FBPase share a sequence motif (Asp-Pro-Ile/Leu-Asp-Gly/Ser-Thr/Ser) which has been shown to bind metal ions and participate in catalysis. This motif is also found in the distantly-related fungal, bacterial and yeast IMPase homologues. It has been suggested that these proteins define an ancient structurally conserved family involved in diverse metabolic pathways, including inositol signalling, gluconeogenesis, sulphate assimilation and possibly quinone metabolism.Three different groups of FBPases have been identified in eukaryotes and bacteria (FBPase I-III). None of these groups have been found in archaea so far, though a new group of FBPases (FBPase IV) which also show inositol monophosphatase activity has recently been identified in archaea.A new group of FBPases (FBPase V) is found in thermophilic archaea and the hyperthermophilic bacterium Aquifex aeolicus. The characterised members of this group show strict substrate specificity for FBP and are suggested to be the true FBPase in these organisms. A structural study suggests that FBPase V has a novel fold for a sugar phosphatase, forming a four-layer alpha-beta-beta-alpha sandwich, unlike the more usual five-layered alpha-beta-alpha-beta-alpha arrangement. The arrangement of the catalytic side chains and metal ligands was found to be consistent with the three-metal ion assisted catalysis mechanism proposed for other FBPases.The fructose 1,6-bisphosphatases found within the Firmicutes (low GC Gram-positive bacteria) do not show any significant sequence similarity to the enzymes from other organisms. The Bacillus subtilis enzyme is inhibited by AMP, though this can be overcome by phosphoenolpyruvate, and is dependent on Mn(2+). Mutants lacking this enzyme are apparently still able to grow on gluconeogenic growth substrates such as malate and glycerol.".
• Fructose_1,6-bisphosphatase arm "q".
• Fructose_1,6-bisphosphatase band "22.3".
• Fructose_1,6-bisphosphatase chromosome "9".
• Fructose_1,6-bisphosphatase ecNumber "3.1.3.11".
• Fructose_1,6-bisphosphatase entrezgene "2203".
• Fructose_1,6-bisphosphatase hgncid "3606".
• Fructose_1,6-bisphosphatase omim "229700".
• Fructose_1,6-bisphosphatase refseq "NM_000507".
• Fructose_1,6-bisphosphatase symbol "FBP".
• Fructose_1,6-bisphosphatase symbol "FBP1".
• Fructose_1,6-bisphosphatase symbol "FBPase".
• Fructose_1,6-bisphosphatase symbol "FBPase_2".
• Fructose_1,6-bisphosphatase symbol "FBPase_3".
• Fructose_1,6-bisphosphatase thumbnail Fructose-1.6-bisphosphatase-pdb-3FBP.png?width=300.
• Fructose_1,6-bisphosphatase uniprot "P09467".
• Fructose_1,6-bisphosphatase wikiPageExternalLink 2284.
• Fructose_1,6-bisphosphatase wikiPageExternalLink explore.do?structureId=3FBP.
• Fructose_1,6-bisphosphatase wikiPageID "316522".
• Fructose_1,6-bisphosphatase wikiPageRevisionID "606064991".
• Fructose_1,6-bisphosphatase altsymbols "FBP".
• Fructose_1,6-bisphosphatase arm "q".
• Fructose_1,6-bisphosphatase band "22.3".
• Fructose_1,6-bisphosphatase caption "Fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex. Rendered from PDB 3FBP.".
• Fructose_1,6-bisphosphatase caption "crystal structure of fructose-1,6-bisphosphatase".
• Fructose_1,6-bisphosphatase caption "crystal structure of rabbit liver fructose-1,6-bisphosphatase at 2.3 angstrom resolution".
• Fructose_1,6-bisphosphatase chromosome "9".
• Fructose_1,6-bisphosphatase ecnumber "3.1".
• Fructose_1,6-bisphosphatase entrezgene "2203".
• Fructose_1,6-bisphosphatase hasPhotoCollection Fructose_1,6-bisphosphatase.
• Fructose_1,6-bisphosphatase hgncid "3606".
• Fructose_1,6-bisphosphatase interpro "IPR000146".
• Fructose_1,6-bisphosphatase interpro "IPR002803".
• Fructose_1,6-bisphosphatase interpro "IPR009164".
• Fructose_1,6-bisphosphatase name "Firmicute fructose-1,6-bisphosphatase".
• Fructose_1,6-bisphosphatase name "Fructose-1,6-bisphosphatase".
• Fructose_1,6-bisphosphatase name "Fructose-1-6-bisphosphatase".
• Fructose_1,6-bisphosphatase name "fructose-1,6-bisphosphatase 1".
• Fructose_1,6-bisphosphatase omim "229700".
• Fructose_1,6-bisphosphatase pfam "PF00316".
• Fructose_1,6-bisphosphatase pfam "PF01950".
• Fructose_1,6-bisphosphatase pfam "PF06874".
• Fructose_1,6-bisphosphatase pfamClan "CL0163".
• Fructose_1,6-bisphosphatase pfamClan "CL0171".
• Fructose_1,6-bisphosphatase prosite "PDOC00114".
• Fructose_1,6-bisphosphatase refseq "NM_000507".
• Fructose_1,6-bisphosphatase scop "1".
• Fructose_1,6-bisphosphatase symbol "FBP1".
• Fructose_1,6-bisphosphatase symbol "FBPase".
• Fructose_1,6-bisphosphatase symbol "FBPase_2".
• Fructose_1,6-bisphosphatase symbol "FBPase_3".
• Fructose_1,6-bisphosphatase uniprot "P09467".
• Fructose_1,6-bisphosphatase width "200".
• Fructose_1,6-bisphosphatase subject Category:EC_3.1.3.
• Fructose_1,6-bisphosphatase subject Category:Protein_families.
• Fructose_1,6-bisphosphatase type Biomolecule.
• Fructose_1,6-bisphosphatase type Protein.
• Fructose_1,6-bisphosphatase type ProteinMolecule.
• Fructose_1,6-bisphosphatase type BiologicalObject.
• Fructose_1,6-bisphosphatase comment "Fructose bisphosphatase (EC 3.1.3.11) is an enzyme that converts fructose-1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis and the Calvin cycle which are both anabolic pathways. Fructose bisphosphatase catalyses the reverse of the reaction which is catalysed by phosphofructokinase in glycolysis.".
• Fructose_1,6-bisphosphatase label "Fructosa-1,6-bisfosfatasa".
• Fructose_1,6-bisphosphatase label "Fructose 1,6-bisphosphatase".
• Fructose_1,6-bisphosphatase label "Fructose-1,6-bisphosphatase".
• Fructose_1,6-bisphosphatase label "Fructose-1,6-bisphosphatase".
• Fructose_1,6-bisphosphatase label "فروكتوز ثنائي الفوسفاتاز".
• Fructose_1,6-bisphosphatase label "フルクトース-1,6-ビスホスファターゼ".
• Fructose_1,6-bisphosphatase sameAs Fructose-1,6-bisphosphatase.
• Fructose_1,6-bisphosphatase sameAs Fructosa-1,6-bisfosfatasa.
• Fructose_1,6-bisphosphatase sameAs Fructose-1,6-bisphosphatase.
• Fructose_1,6-bisphosphatase sameAs フルクトース-1,6-ビスホスファターゼ.
• Fructose_1,6-bisphosphatase sameAs m.01txpm.
• Fructose_1,6-bisphosphatase sameAs Q899507.
• Fructose_1,6-bisphosphatase sameAs Q899507.
• Fructose_1,6-bisphosphatase wasDerivedFrom Fructose_1,6-bisphosphatase?oldid=606064991.
• Fructose_1,6-bisphosphatase depiction Fructose-1.6-bisphosphatase-pdb-3FBP.png.
• Fructose_1,6-bisphosphatase isPrimaryTopicOf Fructose_1,6-bisphosphatase.
• Fructose_1,6-bisphosphatase name "fructose-1,6-bisphosphatase 1".