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- GLYX-13 abstract "GLYX-13 is a nootropic partial agonist of the NMDA receptor - specifically at the glycine binding site. It has been shown to enhance memory and learning in both young adult and learning-impaired, aging rat models. GLYX-13, a tetrapeptide (H-Thr-Pro-Pro-Thr-NH2), readily crosses the blood brain barrier and has been shown to increase Schaffer collateral-CA1 LTP in vitro. In concert with a learning task it has also been shown to elevate gene expression of hippocampal NR1, a subunit of the NMDA receptor, in 3-month-old rats. Neuroprotective effects have also been demonstrated in Mongolian Gerbils by delaying the death of CA1, CA3, and dentate gyrus pyramidal neurons under glucose and oxygen-deprived conditions. Preclinical data indicates that GLYX-13 has a therapeutic index of 500 or more, onset within 20 minutes of administration, and produces antidepressant-like effects lasting approximately two weeks following administration. Currently under development by Naurex Inc, the compound recently completed phase II trials as a treatment for those resistant or non-responsive to traditional antidepressants. On March 3, 2014 the FDA granted Fast Track designation to the investigation of GLYX-13 as adjunctive therapy in major depressive disorder.Additionally, GLYX-13 has demonstrated antinociceptive activity, which is of particular interest, as both competitive and noncompetitive NMDA receptor antagonists are ataxic at analgesic doses, while GLYX-13 and other glycine subunit ligands are able to elicit analgesia at sub-ataxic doses.".
- GLYX-13 atcPrefix "none".
- GLYX-13 casNumber "117928-94-6".
- GLYX-13 iupacName "(S)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-1-[(S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide".
- GLYX-13 thumbnail GLYX-13_structure.png?width=300.
- GLYX-13 wikiPageID "37227776".
- GLYX-13 wikiPageRevisionID "603104692".
- GLYX-13 atcPrefix "none".
- GLYX-13 c "18".
- GLYX-13 casNumber "117928".
- GLYX-13 drugName "GLYX-13".
- GLYX-13 h "31".
- GLYX-13 hasPhotoCollection GLYX-13.
- GLYX-13 image "GLYX-133Dan.gif".
- GLYX-13 iupacName "-N-[-1-amino-3-hydroxy-1-oxobutan-2-yl]-1-[-1-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide".
- GLYX-13 legalStatus "Investigational New Drug".
- GLYX-13 molecularWeight "413.47".
- GLYX-13 n "5".
- GLYX-13 o "6".
- GLYX-13 pregnancyUs "N".
- GLYX-13 width "250".
- GLYX-13 subject Category:Drugs.
- GLYX-13 subject Category:NMDA_receptor_agonists.
- GLYX-13 subject Category:Nootropics.
- GLYX-13 subject Category:Psychoactive_drugs.
- GLYX-13 type Drug.
- GLYX-13 type FunctionalSubstance.
- GLYX-13 comment "GLYX-13 is a nootropic partial agonist of the NMDA receptor - specifically at the glycine binding site. It has been shown to enhance memory and learning in both young adult and learning-impaired, aging rat models. GLYX-13, a tetrapeptide (H-Thr-Pro-Pro-Thr-NH2), readily crosses the blood brain barrier and has been shown to increase Schaffer collateral-CA1 LTP in vitro.".
- GLYX-13 label "GLYX-13".
- GLYX-13 sameAs m.0n52q16.
- GLYX-13 sameAs Q5513673.
- GLYX-13 sameAs Q5513673.
- GLYX-13 wasDerivedFrom GLYX-13?oldid=603104692.
- GLYX-13 depiction GLYX-13_structure.png.
- GLYX-13 isPrimaryTopicOf GLYX-13.
- GLYX-13 name "GLYX-13".
