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- GW-405,833 abstract "GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the cannabinoid receptor subtype CB2, with an EC50 of 0.65nM and selectivity of around 1200x for CB2 over CB1 receptors. Animal studies have shown it to possess antiinflammatory and anti-hyperalgesic effects at low doses, followed by ataxia and analgesic effects when the dose is increased. Selective CB2 agonist drugs such as GW-405,833 are hoped to be particularly useful in the treatment of allodynia and neuropathic pain for which current treatment options are often inadequate.".
- GW-405,833 casNumber "180002-83-9".
- GW-405,833 iupacName "1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole".
- GW-405,833 pubchem "9911463".
- GW-405,833 thumbnail GW-405,833-2D-skeletal.svg?width=300.
- GW-405,833 wikiPageID "22228597".
- GW-405,833 wikiPageRevisionID "567034985".
- GW-405,833 c "23".
- GW-405,833 casNumber "180002".
- GW-405,833 chembl "73711".
- GW-405,833 cl "2".
- GW-405,833 h "24".
- GW-405,833 hasPhotoCollection GW-405,833.
- GW-405,833 iupacName "1".
- GW-405,833 molecularWeight "447.353".
- GW-405,833 n "2".
- GW-405,833 o "3".
- GW-405,833 pubchem "9911463".
- GW-405,833 smiles "C4COCCN4CCc1cnCc2ccccc2Cl".
- GW-405,833 verifiedfields "changed".
- GW-405,833 verifiedrevid "424782539".
- GW-405,833 width "240".
- GW-405,833 subject Category:Aminoalkylindoles.
- GW-405,833 subject Category:Benzoylindoles.
- GW-405,833 subject Category:CB2_receptor_agonist.
- GW-405,833 subject Category:Cannabinoids.
- GW-405,833 subject Category:Morpholines.
- GW-405,833 subject Category:Organochlorides.
- GW-405,833 subject Category:Phenol_ethers.
- GW-405,833 type Drug.
- GW-405,833 type DrugProduct.
- GW-405,833 type FunctionalSubstance.
- GW-405,833 comment "GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the cannabinoid receptor subtype CB2, with an EC50 of 0.65nM and selectivity of around 1200x for CB2 over CB1 receptors. Animal studies have shown it to possess antiinflammatory and anti-hyperalgesic effects at low doses, followed by ataxia and analgesic effects when the dose is increased.".
- GW-405,833 label "GW-405,833".
- GW-405,833 sameAs m.05q6dcm.
- GW-405,833 sameAs Q5514865.
- GW-405,833 sameAs Q5514865.
- GW-405,833 wasDerivedFrom GW-405,833?oldid=567034985.
- GW-405,833 depiction GW-405,833-2D-skeletal.svg.
- GW-405,833 isPrimaryTopicOf GW-405,833.