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- Gadopentetic_acid abstract "Gadopentetic acid is one of the trade names for a gadolinium -based MRI contrast agent, usually administered as a salt of a complex of gadolinium with DTPA (diethylenetriaminepentacetate ) with the chemical formula A2[Gd(DTPA)(H2O)]; when cation A is the protonated form of the amino sugar meglumine the salt goes under the name "Gadopentetate dimeglumine". It was described in 1981 and introduced as the first MRI contrast agent in 1987. It is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood–brain barrier. It is usually injected intravenously. Gd-DTPA is classed as an acyclic, ionic gadolinium contrast medium. Its paramagnetic property reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in NMR, which is the source of its clinical utility.Marketed as Magnevist by Bayer Schering Pharma, it was the first intravenous contrast agent to become available for clinical use, and is in widespread use around the world. Similar contrast agents are Dotarem (gadoterate) manufactured by Guerbet, MultiHance (gadobenate dimeglumine) and ProHance (gadoteridol) manufactured by Bracco, Omniscan (gadodiamide) manufactured by GE Healthcare, and OptiMARK (gadoversetamide) manufactured by Mallinckrodt.Gadolinium based agents may cause a toxic reaction known as nephrogenic systemic fibrosis (NSF) in patients with severe kidney problems.Compared to other gadolinium-based MRI contrast agents, Gadopentetate dimeglumine (Gd-DTPA2-) chelates allow delayed Gadolinium-enhanced Magnetic Resonance of Cartilage (dGEMRIC). The unique charge characteristic of this complex allows researchers to inversely measure spin-lattice relaxation times as they are related to the concentration of proteoglycan aggregates and charged glycosaminoglycan side chains in articular cartilage.".
- Gadopentetic_acid atcPrefix "V08".
- Gadopentetic_acid atcSuffix "CA01".
- Gadopentetic_acid casNumber "86050-77-3".
- Gadopentetic_acid chEBI "31797".
- Gadopentetic_acid drugbank "DB00789".
- Gadopentetic_acid fdaUniiCode "RH248G8V27".
- Gadopentetic_acid pubchem "55466".
- Gadopentetic_acid thumbnail Gd(DTPA)(aq)2-.png?width=300.
- Gadopentetic_acid wikiPageExternalLink index.html?WT.mc_id=berleximaging.com.
- Gadopentetic_acid wikiPageExternalLink index.php.
- Gadopentetic_acid wikiPageExternalLink serv1.php?type=db1&dbs=Gadopentetate%20Dimeglumine.
- Gadopentetic_acid wikiPageID "4388553".
- Gadopentetic_acid wikiPageRevisionID "606663744".
- Gadopentetic_acid atcPrefix "V08".
- Gadopentetic_acid atcSuffix "CA01".
- Gadopentetic_acid c "14".
- Gadopentetic_acid casNumber "86050".
- Gadopentetic_acid chebi "31797".
- Gadopentetic_acid chembl "1200431".
- Gadopentetic_acid chemspiderid "50087".
- Gadopentetic_acid drugbank "DB00789".
- Gadopentetic_acid eliminationHalfLife "6000.0".
- Gadopentetic_acid gd "1".
- Gadopentetic_acid h "18".
- Gadopentetic_acid hasPhotoCollection Gadopentetic_acid.
- Gadopentetic_acid inchi "1".
- Gadopentetic_acid inchikey "LGMLJQFQKXPRGA-TTXANEAOBX".
- Gadopentetic_acid kegg "D01707".
- Gadopentetic_acid n "3".
- Gadopentetic_acid o "10".
- Gadopentetic_acid pubchem "55466".
- Gadopentetic_acid smiles "[Gd+3].[O-]CCNCCNCCO.O[C@H][C@H][C@H]CO.O[C@@H][C@@H][C@H][C@H]CO".
- Gadopentetic_acid stdinchi "1".
- Gadopentetic_acid stdinchikey "LGMLJQFQKXPRGA-VPVMAENOSA-K".
- Gadopentetic_acid unii "RH248G8V27".
- Gadopentetic_acid verifiedfields "changed".
- Gadopentetic_acid verifiedrevid "476997570".
- Gadopentetic_acid watchedfields "changed".
- Gadopentetic_acid subject Category:MRI_contrast_agents.
- Gadopentetic_acid subject Category:Organogadolinium_compounds.
- Gadopentetic_acid type Abstraction100002137.
- Gadopentetic_acid type Cognition100023271.
- Gadopentetic_acid type Compound105870180.
- Gadopentetic_acid type Concept105835747.
- Gadopentetic_acid type Content105809192.
- Gadopentetic_acid type Idea105833840.
- Gadopentetic_acid type OrganogadoliniumCompounds.
- Gadopentetic_acid type PsychologicalFeature100023100.
- Gadopentetic_acid type Whole105869584.
- Gadopentetic_acid type Drug.
- Gadopentetic_acid type DrugProduct.
- Gadopentetic_acid type FunctionalSubstance.
- Gadopentetic_acid comment "Gadopentetic acid is one of the trade names for a gadolinium -based MRI contrast agent, usually administered as a salt of a complex of gadolinium with DTPA (diethylenetriaminepentacetate ) with the chemical formula A2[Gd(DTPA)(H2O)]; when cation A is the protonated form of the amino sugar meglumine the salt goes under the name "Gadopentetate dimeglumine". It was described in 1981 and introduced as the first MRI contrast agent in 1987.".
- Gadopentetic_acid label "Gadopentetat-Dimeglumin".
- Gadopentetic_acid label "Gadopentetic acid".
- Gadopentetic_acid sameAs Gadopentetat-Dimeglumin.
- Gadopentetic_acid sameAs m.0b_m1n.
- Gadopentetic_acid sameAs Q413793.
- Gadopentetic_acid sameAs Q413793.
- Gadopentetic_acid sameAs DB00789.
- Gadopentetic_acid sameAs Gadopentetic_acid.
- Gadopentetic_acid wasDerivedFrom Gadopentetic_acid?oldid=606663744.
- Gadopentetic_acid depiction Gd(DTPA)(aq)2-.png.
- Gadopentetic_acid isPrimaryTopicOf Gadopentetic_acid.