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- Gamendazole abstract "Gamendazole is a novel drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). Gamendazole produced 100% antispermatogenic effects at 25 mg/kg i.p. in rats, whereas 200 mg/kg was fatal for 60% of rats tested. Since gamendazole produced 100% efficacy, it was tested orally. At a dose of 6 mg/kg, 100% of rats were infertile 4 weeks after a single administration. Complete infertility was maintained for 2 weeks, followed by complete recovery in 4 of 7 rats. The other 3 never recovered fertility. Upon dosing 6 mg/kg orally for 7 days, it produced similar infertility results, but only 2 of 7 rats recovered fertility. There were no abnormalities in rates of conception or abnormal conception in rats who recovered fertility.Pathology reports were conducted on gamendazole treated rats. At 25 mg/kg i.p., 6 mg/kg oral, and in animals that survived 200 mg/kg i.p., there were no remarkable findings, with no evidence of inflammation, necrosis, tumors, or hemorrhage. There was also a lack of observable behavioral effects at 25 mg/kg i.p., 6 mg/kg oral, and in animals that survived 200 mg/kg i.p. Gamendazole treatment had no effect on testosterone levels, and was reported to affect Sertoli cell function, leading to decreased levels of inhibin B. Low levels of inhibin B were correlated to the infertility of the rat.".
- Gamendazole iupacName "(E)-3-[1-[(2,4-Dichlorophenyl)methyl]-6-(trifluoromethyl)indazol-3-yl]prop-2-enoic acid".
- Gamendazole thumbnail Gamendazole.svg?width=300.
- Gamendazole wikiPageID "32596353".
- Gamendazole wikiPageRevisionID "591407356".
- Gamendazole hasPhotoCollection Gamendazole.
- Gamendazole imagefile "Gamendazole.svg".
- Gamendazole imagesize "200".
- Gamendazole iupacname "-3".
- Gamendazole othernames "trans-3-acrylic acid)".
- Gamendazole verifiedfields "changed".
- Gamendazole verifiedrevid "442713318".
- Gamendazole watchedfields "changed".
- Gamendazole subject Category:Carboxylic_acids.
- Gamendazole subject Category:Contraception_for_males.
- Gamendazole subject Category:Experimental_methods_of_birth_control.
- Gamendazole subject Category:Indazoles.
- Gamendazole type Ability105616246.
- Gamendazole type Abstraction100002137.
- Gamendazole type Acid114607521.
- Gamendazole type CarboxylicAcid114739360.
- Gamendazole type CarboxylicAcids.
- Gamendazole type Chemical114806838.
- Gamendazole type Cognition100023271.
- Gamendazole type Compound114818238.
- Gamendazole type ExperimentalMethod105660801.
- Gamendazole type ExperimentalMethodsOfBirthControl.
- Gamendazole type Know-how105616786.
- Gamendazole type Material114580897.
- Gamendazole type Matter100020827.
- Gamendazole type Method105660268.
- Gamendazole type Methodology105661400.
- Gamendazole type Part113809207.
- Gamendazole type PhysicalEntity100001930.
- Gamendazole type PsychologicalFeature100023100.
- Gamendazole type Relation100031921.
- Gamendazole type ScientificMethod105660631.
- Gamendazole type Substance100019613.
- Gamendazole type ChemicalCompound.
- Gamendazole type ChemicalSubstance.
- Gamendazole type ChemicalObject.
- Gamendazole type Thing.
- Gamendazole comment "Gamendazole is a novel drug candidate for male contraception. It is an indazole carboxylic acid derived from lonidamine (LND). Gamendazole produced 100% antispermatogenic effects at 25 mg/kg i.p. in rats, whereas 200 mg/kg was fatal for 60% of rats tested. Since gamendazole produced 100% efficacy, it was tested orally. At a dose of 6 mg/kg, 100% of rats were infertile 4 weeks after a single administration.".
- Gamendazole label "Gamendazole".
- Gamendazole sameAs m.0h1hpd5.
- Gamendazole sameAs Q5520039.
- Gamendazole sameAs Q5520039.
- Gamendazole sameAs Gamendazole.
- Gamendazole wasDerivedFrom Gamendazole?oldid=591407356.
- Gamendazole depiction Gamendazole.svg.
- Gamendazole isPrimaryTopicOf Gamendazole.