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- Geldanamycin abstract "Geldanamycin is a benzoquinone ansamycin antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate such as hepatotoxicity, further, Jilani et al. reported that geldanamycin induces eryptosis (apoptosis of erythrocytes) under physiological concentrations. These side effects have led to the development of geldanamycin analogues, in particular analogues containing a derivatisation at the 17 position: 17-AAG 17-DMAG↑ ↑ ↑".
- Geldanamycin iupacName "(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy".
- Geldanamycin iupacName "-3,20,22-trioxo-2-azabicyclo[16.3.1]".
- Geldanamycin iupacName "-8,14,19-trimethoxy-4,10,12,16-tetramethyl".
- Geldanamycin iupacName "docosa-1(21),4,6,10,18-pentaen-9-yl carbamate".
- Geldanamycin thumbnail Geldanamycin.svg?width=300.
- Geldanamycin wikiPageExternalLink index.htm.
- Geldanamycin wikiPageExternalLink ?ligand=GDM.
- Geldanamycin wikiPageExternalLink geldanamycin.htm.
- Geldanamycin wikiPageID "4041200".
- Geldanamycin wikiPageRevisionID "586280554".
- Geldanamycin hasPhotoCollection Geldanamycin.
- Geldanamycin imagefile "Geldanamycin.svg".
- Geldanamycin iupacname "-13".
- Geldanamycin iupacname "-32022".
- Geldanamycin iupacname "-81419".
- Geldanamycin iupacname "docosa-1,4,6,10,18-pentaen-9-yl carbamate".
- Geldanamycin verifiedrevid "443833298".
- Geldanamycin subject Category:Alcohols.
- Geldanamycin subject Category:Antibiotics.
- Geldanamycin subject Category:Carbamates.
- Geldanamycin subject Category:Ethers.
- Geldanamycin subject Category:Lactams.
- Geldanamycin subject Category:Phenol_ethers.
- Geldanamycin subject Category:Quinones.
- Geldanamycin type Abstraction100002137.
- Geldanamycin type Agent114778436.
- Geldanamycin type Alcohol107884567.
- Geldanamycin type Alcohols.
- Geldanamycin type Beverage107881800.
- Geldanamycin type Carbamate114792281.
- Geldanamycin type Carbamates.
- Geldanamycin type CausalAgent100007347.
- Geldanamycin type Chemical114806838.
- Geldanamycin type Compound114818238.
- Geldanamycin type Drug103247620.
- Geldanamycin type DrugOfAbuse103248958.
- Geldanamycin type Element114840755.
- Geldanamycin type Ethers.
- Geldanamycin type Fluid114939900.
- Geldanamycin type Food100021265.
- Geldanamycin type Liquid114940386.
- Geldanamycin type Material114580897.
- Geldanamycin type Matter100020827.
- Geldanamycin type Part113809207.
- Geldanamycin type PhenolEthers.
- Geldanamycin type PhysicalEntity100001930.
- Geldanamycin type Quinone115000973.
- Geldanamycin type Quinones.
- Geldanamycin type Quintessence114847103.
- Geldanamycin type Relation100031921.
- Geldanamycin type Salt115010703.
- Geldanamycin type Substance100019613.
- Geldanamycin type Substance100020090.
- Geldanamycin type ChemicalCompound.
- Geldanamycin type ChemicalSubstance.
- Geldanamycin type ChemicalSubstanceType.
- Geldanamycin type ChemicalObject.
- Geldanamycin type Thing.
- Geldanamycin comment "Geldanamycin is a benzoquinone ansamycin antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts.".
- Geldanamycin label "Geldanamicina".
- Geldanamycin label "Geldanamycin".
- Geldanamycin label "Geldanamycin".
- Geldanamycin label "Geldanamycine".
- Geldanamycin label "Geldanamycyna".
- Geldanamycin sameAs Geldanamycin.
- Geldanamycin sameAs Geldanamycine.
- Geldanamycin sameAs Geldanamicina.
- Geldanamycin sameAs Geldanamycyna.
- Geldanamycin sameAs m.0bf0yp.
- Geldanamycin sameAs Q904475.
- Geldanamycin sameAs Q904475.
- Geldanamycin sameAs DB02424.
- Geldanamycin sameAs Geldanamycin.
- Geldanamycin wasDerivedFrom Geldanamycin?oldid=586280554.
- Geldanamycin depiction Geldanamycin.svg.
- Geldanamycin isPrimaryTopicOf Geldanamycin.