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- Gentamicin abstract "Gentamicin is an aminoglycoside antibiotic composed of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. However, gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila. Gentamicin is also ototoxic and nephrotoxic, with this toxicity remaining a major problem in clinical use.It is synthesized by Micromonospora, a genus of Gram-positive bacteria widely present in the environment (water and soil). To highlight their specific biological origins, gentamicin and other related antibiotics produced by this genus (verdamicin, mutamicin, sisomicin, netilmicin, retymicin) generally have their spellings ending in ~micin and not in ~mycin. Gentamicin is a bactericidal antibiotic that works by binding the 30S subunit of the bacterial ribosome, interrupting protein synthesis.Like all aminoglycosides, when gentamicin is given orally, it is not systemically active. This is because it is not absorbed to any appreciable extent from the small intestine. It is administered intravenously, intramuscularly or topically to treat infections. It appears to be completely eliminated unchanged in the urine. Urine must be collected for many days to recover all of a given dose because the drug binds avidly to certain tissues.E. coli has shown some resistance to gentamicin, despite being Gram-negative. Reluctance to use gentamicin for empirical therapy has led to increased use of alternative broad-spectrum antibiotics, which some experts suggest has led to the prevalence of antibiotic-resistant bacterial infections by MRSA and other so-called "superbugs".Gentamicin is one of the few heat-stable antibiotics that remain active even after autoclaving, which makes it particularly useful in the preparation of some microbiological growth media. It is used during orthopaedic surgery when high temperatures are required for the setting of cements (e.g. hip replacements).It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.".
- Gentamicin atcPrefix "D06".
- Gentamicin atcSuffix "AX07".
- Gentamicin casNumber "1403-66-3".
- Gentamicin chEBI "27412".
- Gentamicin drugbank "DB00798".
- Gentamicin fdaUniiCode "T6Z9V48IKG".
- Gentamicin iupacName "(3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-".
- Gentamicin iupacName "1-(methylamino)ethyl]oxan-2-yl]oxy}-".
- Gentamicin iupacName "2-hydroxycyclohexyl]oxy}-5-methyl-".
- Gentamicin iupacName "3-amino-6-[(1R)-".
- Gentamicin iupacName "4-(methylamino)oxane-3,5-diol".
- Gentamicin iupacName "diamino-3-{[(2R,3R,6S)-".
- Gentamicin pubchem "3467".
- Gentamicin thumbnail Gentamicin_C2.svg?width=300.
- Gentamicin wikiPageID "254717".
- Gentamicin wikiPageRevisionID "605283615".
- Gentamicin atcPrefix "D06".
- Gentamicin atcSuffix "AX07".
- Gentamicin bioavailability "limited oral bioavailability".
- Gentamicin c "21".
- Gentamicin casNumber "1403".
- Gentamicin chebi "27412".
- Gentamicin chembl "195892".
- Gentamicin chemspiderid "390067".
- Gentamicin drugbank "DB00798".
- Gentamicin eliminationHalfLife "7200.0".
- Gentamicin excretion "renal".
- Gentamicin h "43".
- Gentamicin hasPhotoCollection Gentamicin.
- Gentamicin image "Gentamicin.png".
- Gentamicin inchi "1".
- Gentamicin iupacName "-2".
- Gentamicin iupacName "1".
- Gentamicin iupacName "2".
- Gentamicin iupacName "3".
- Gentamicin iupacName "4".
- Gentamicin iupacName "diamino-3-{[-".
- Gentamicin iupharLigand "2427".
- Gentamicin kegg "D08013".
- Gentamicin legalUk "POM".
- Gentamicin medlineplus "a682275".
- Gentamicin molecularWeight "477.596".
- Gentamicin n "5".
- Gentamicin o "7".
- Gentamicin pregnancyCategory "D".
- Gentamicin proteinBound "0".
- Gentamicin pubchem "3467".
- Gentamicin routesOfAdministration Eye_drop.
- Gentamicin routesOfAdministration Intramuscular_injection.
- Gentamicin routesOfAdministration Intravenous_therapy.
- Gentamicin routesOfAdministration Topical_medication.
- Gentamicin smiles "O[C@]3[C@H][C@@H][C@@H]OC3".
- Gentamicin stdinchi "1".
- Gentamicin stdinchikey "CEAZRRDELHUEMR-URQXQFDESA-N".
- Gentamicin unii "T6Z9V48IKG".
- Gentamicin verifiedfields "changed".
- Gentamicin verifiedrevid "443833957".
- Gentamicin width "350".
- Gentamicin subject Category:Aminoglycoside_antibiotics.
- Gentamicin subject Category:Otologicals.
- Gentamicin subject Category:Toxicology.
- Gentamicin subject Category:World_Health_Organization_essential_medicines.
- Gentamicin type Drug.
- Gentamicin type DrugProduct.
- Gentamicin type FunctionalSubstance.
- Gentamicin comment "Gentamicin is an aminoglycoside antibiotic composed of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms. However, gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila.".
- Gentamicin label "Gentamicin".
- Gentamicin label "Gentamicin".
- Gentamicin label "Gentamicina".
- Gentamicin label "Gentamicina".
- Gentamicin label "Gentamicina".
- Gentamicin label "Gentamicine".
- Gentamicin label "Gentamicine".
- Gentamicin label "Gentamycyna".
- Gentamicin label "Гентамицин".
- Gentamicin label "جنتاميسين".
- Gentamicin label "ゲンタマイシン".
- Gentamicin label "庆大霉素".
- Gentamicin sameAs Gentamicin.
- Gentamicin sameAs Gentamicin.
- Gentamicin sameAs Gentamicina.
- Gentamicin sameAs Gentamicine.
- Gentamicin sameAs Gentamicina.
- Gentamicin sameAs ゲンタマイシン.
- Gentamicin sameAs Gentamicine.
- Gentamicin sameAs Gentamycyna.
- Gentamicin sameAs Gentamicina.
- Gentamicin sameAs m.01lrtb.
- Gentamicin sameAs Q422482.
- Gentamicin sameAs Q422482.
- Gentamicin sameAs Gentamicin.
- Gentamicin sameAs DB00798.
- Gentamicin wasDerivedFrom Gentamicin?oldid=605283615.
- Gentamicin depiction Gentamicin_C2.svg.
- Gentamicin isPrimaryTopicOf Gentamicin.