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- Grapefruit–drug_interactions abstract "Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 by the latest count), in many cases resulting in adverse effects. Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Some grapefruit-pomelo hybrids have practically no furanocoumarin content, and one is a commercially viable seedless type.".
- Grapefruit–drug_interactions thumbnail Citrus_paradisi_(Grapefruit,_pink)_white_bg.jpg?width=300.
- Grapefruit–drug_interactions wikiPageID "4387617".
- Grapefruit–drug_interactions wikiPageRevisionID "606784297".
- Grapefruit–drug_interactions date "April 2013".
- Grapefruit–drug_interactions reason "affected how?".
- Grapefruit–drug_interactions subject Category:Grapefruit.
- Grapefruit–drug_interactions subject Category:Medical_lists.
- Grapefruit–drug_interactions subject Category:Pharmacology.
- Grapefruit–drug_interactions comment "Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 by the latest count), in many cases resulting in adverse effects. Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme.".
- Grapefruit–drug_interactions label "Grapefruit–drug interactions".
- Grapefruit–drug_interactions sameAs Grapefruit%E2%80%93drug_interactions.
- Grapefruit–drug_interactions sameAs Q5597010.
- Grapefruit–drug_interactions sameAs Q5597010.
- Grapefruit–drug_interactions wasDerivedFrom Grapefruit–drug_interactions?oldid=606784297.
- Grapefruit–drug_interactions depiction Citrus_paradisi_(Grapefruit,_pink)_white_bg.jpg.
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