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- Guanylate_cyclase abstract "Guanylate cyclase (EC 4.6.1.2, also known as guanylyl cyclase, guanyl cyclase, or GC) is a lyase enzyme. Guanylate cyclase is part of the G protein (does not use the G protein cascade in vertebrates) signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylyl cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell. Like cAMP, cGMP is an important second messenger that internalizes the message carried by intercellular messengers such as peptide hormones and NO, and can also function as an autocrine signal. Depending on cell type, it can drive adaptive/developmental changes requiring protein synthesis. In smooth muscle, cGMP is the signal for relaxation, and is coupled to many homeostaic mechanisms including regulation of vascular and airway tone, insulin secretion, and peristalsis. Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on the tissue.".
- Guanylate_cyclase ecNumber "4.6.1.2".
- Guanylate_cyclase thumbnail 3uvj.png?width=300.
- Guanylate_cyclase wikiPageID "572637".
- Guanylate_cyclase wikiPageRevisionID "567877453".
- Guanylate_cyclase caption "catalytic domain of human soluble guanylate cyclase 1. PDB".
- Guanylate_cyclase casNumber "9054".
- Guanylate_cyclase ecNumber "4.6".
- Guanylate_cyclase goCode "8075".
- Guanylate_cyclase hasPhotoCollection Guanylate_cyclase.
- Guanylate_cyclase iubmbEcNumber "4".
- Guanylate_cyclase name "Guanylate cyclase".
- Guanylate_cyclase subject Category:EC_4.6.1.
- Guanylate_cyclase subject Category:Hemoproteins.
- Guanylate_cyclase type Abstraction100002137.
- Guanylate_cyclase type Chemical114806838.
- Guanylate_cyclase type Compound114818238.
- Guanylate_cyclase type ConjugatedProtein114731135.
- Guanylate_cyclase type Hemoprotein114888884.
- Guanylate_cyclase type Hemoproteins.
- Guanylate_cyclase type Macromolecule114944888.
- Guanylate_cyclase type Material114580897.
- Guanylate_cyclase type Matter100020827.
- Guanylate_cyclase type Molecule114682133.
- Guanylate_cyclase type OrganicCompound114727670.
- Guanylate_cyclase type Part113809207.
- Guanylate_cyclase type PhysicalEntity100001930.
- Guanylate_cyclase type Protein114728724.
- Guanylate_cyclase type Relation100031921.
- Guanylate_cyclase type Substance100019613.
- Guanylate_cyclase type Thing100002452.
- Guanylate_cyclase type Unit109465459.
- Guanylate_cyclase type Biomolecule.
- Guanylate_cyclase type Enzyme.
- Guanylate_cyclase type BiologicalObject.
- Guanylate_cyclase comment "Guanylate cyclase (EC 4.6.1.2, also known as guanylyl cyclase, guanyl cyclase, or GC) is a lyase enzyme. Guanylate cyclase is part of the G protein (does not use the G protein cascade in vertebrates) signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylyl cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.".
- Guanylate_cyclase label "Cyklaza guanylowa".
- Guanylate_cyclase label "Guanilato ciclasi".
- Guanylate_cyclase label "Guanylate cyclase".
- Guanylate_cyclase label "Guanylate cyclase".
- Guanylate_cyclase label "Guanylylcyclasen".
- Guanylate_cyclase label "グアニル酸シクラーゼ".
- Guanylate_cyclase sameAs Guanylylcyclasen.
- Guanylate_cyclase sameAs Guanylate_cyclase.
- Guanylate_cyclase sameAs Guanilato_ciclasi.
- Guanylate_cyclase sameAs グアニル酸シクラーゼ.
- Guanylate_cyclase sameAs Cyklaza_guanylowa.
- Guanylate_cyclase sameAs m.02rc8h.
- Guanylate_cyclase sameAs Q419566.
- Guanylate_cyclase sameAs Q419566.
- Guanylate_cyclase sameAs Guanylate_cyclase.
- Guanylate_cyclase wasDerivedFrom Guanylate_cyclase?oldid=567877453.
- Guanylate_cyclase depiction 3uvj.png.
- Guanylate_cyclase isPrimaryTopicOf Guanylate_cyclase.
- Guanylate_cyclase name "Guanylate cyclase".