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- HA-966 abstract "HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist. It has neuroprotective and anticonvulsant, anxiolytic, antinociceptive and sedative / hypnotic effects in animal models. Pilot human clinical trials in the early 1960s showed that HA-966 appeared to benefit patients with tremors of extrapyramidal origin.The two enantiomers of HA-966 have differing pharmacological activity. The glycine/N-methyl-D-aspartate receptor antagonist activity is specific to the R-(+) enantiomer, whereas the sedative and ataxic effects are specific to the S-(-) enantiomer.R-(+)-HA-966 did not induce drug-appropriate responding in animals trained to discriminate phencyclidine (PCP) from saline, suggesting that the glycine receptor ligand R-(+)-HA-966 has a significantly different behavioral profile than drugs affecting the ion channel of the NMDA receptor complex.S-(-)-HA-966 has been described as a "γ-hydroxybutyric acid (GHB)-like agent" and a "potent y-butyrolactone-like sedative", but it shows no affinity for the GABAB receptor (GABABR).".
- HA-966 casNumber "1003-51-6".
- HA-966 iupacName "3-Amino-1-hydroxy-pyrrolidin-2-one".
- HA-966 pubchem "1232".
- HA-966 thumbnail Molecular_Structure_of_HA-966.png?width=300.
- HA-966 wikiPageID "36399227".
- HA-966 wikiPageRevisionID "591565276".
- HA-966 c "4".
- HA-966 casNumber "1003".
- HA-966 chemspiderid "1195".
- HA-966 h "8".
- HA-966 hasPhotoCollection HA-966.
- HA-966 inchi "1".
- HA-966 inchikey "HCKUBNLZMKAEIN-UHFFFAOYAL".
- HA-966 iupacName "3".
- HA-966 molecularWeight "116.11972".
- HA-966 n "2".
- HA-966 o "2".
- HA-966 pubchem "1232".
- HA-966 smiles "O=C1CN".
- HA-966 stdinchi "1".
- HA-966 stdinchikey "HCKUBNLZMKAEIN-UHFFFAOYSA-N".
- HA-966 width "200".
- HA-966 subject Category:Pyrrolidines.
- HA-966 subject Category:AMPA_agonists.
- HA-966 subject Category:Glutaminergics.
- HA-966 type Drug.
- HA-966 type FunctionalSubstance.
- HA-966 comment "HA-966 or (±) 3-Amino-1-hydroxy-pyrrolidin-2-one is a molecule used in scientific research as a glycine receptor and NMDA receptor antagonist / low efficacy partial agonist. It has neuroprotective and anticonvulsant, anxiolytic, antinociceptive and sedative / hypnotic effects in animal models. Pilot human clinical trials in the early 1960s showed that HA-966 appeared to benefit patients with tremors of extrapyramidal origin.The two enantiomers of HA-966 have differing pharmacological activity.".
- HA-966 label "HA-966".
- HA-966 sameAs m.0k8sxlq.
- HA-966 sameAs Q5628879.
- HA-966 sameAs Q5628879.
- HA-966 wasDerivedFrom HA-966?oldid=591565276.
- HA-966 depiction Molecular_Structure_of_HA-966.png.
- HA-966 isPrimaryTopicOf HA-966.