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- HDMP-28 abstract "HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the phenyl ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. Most of the TMP analogs of HDMP-28 have SERT Ki values in the range >10,000 and so are selective for dopamine and noradrenaline reuptake, with little or no effect on serotonin. HDMP-28 also has high affinity to SERT, and so behaves as a triple reuptake inhibitor.D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT.A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration.".
- HDMP-28 iupacName "methyl (2R)-2-naphthyl[(2R)-piperidin-2-yl]acetate".
- HDMP-28 pubchem "9817261".
- HDMP-28 thumbnail HDMP-28.png?width=300.
- HDMP-28 wikiPageID "17824721".
- HDMP-28 wikiPageRevisionID "602590596".
- HDMP-28 c "18".
- HDMP-28 chemspiderid "7993011".
- HDMP-28 h "21".
- HDMP-28 hasPhotoCollection HDMP-28.
- HDMP-28 inchi "1".
- HDMP-28 inchikey "DNRNSIJBSCBESJ-IAGOWNOFBM".
- HDMP-28 iupacName "methyl -2-naphthyl[-piperidin-2-yl]acetate".
- HDMP-28 molecularWeight "283.365".
- HDMP-28 n "1".
- HDMP-28 o "2".
- HDMP-28 pubchem "9817261".
- HDMP-28 smiles "O=C[C@H][C@@H]3NCCCC3".
- HDMP-28 smiles "O=C[C@H][C@]3CCCCN3".
- HDMP-28 stdinchi "1".
- HDMP-28 stdinchikey "DNRNSIJBSCBESJ-IAGOWNOFSA-N".
- HDMP-28 verifiedfields "changed".
- HDMP-28 verifiedrevid "443274732".
- HDMP-28 watchedfields "changed".
- HDMP-28 width "220".
- HDMP-28 subject Category:Dopamine_reuptake_inhibitors.
- HDMP-28 subject Category:Naphthalenes.
- HDMP-28 subject Category:Piperidines.
- HDMP-28 subject Category:Stimulants.
- HDMP-28 type Drug.
- HDMP-28 type DrugProduct.
- HDMP-28 type FunctionalSubstance.
- HDMP-28 comment "HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the phenyl ring replaced by naphthalene.".
- HDMP-28 label "HDMP-28".
- HDMP-28 sameAs m.0478w55.
- HDMP-28 sameAs Q5629209.
- HDMP-28 sameAs Q5629209.
- HDMP-28 wasDerivedFrom HDMP-28?oldid=602590596.
- HDMP-28 depiction HDMP-28.png.
- HDMP-28 isPrimaryTopicOf HDMP-28.