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- HES1 abstract "Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box promoter region rather than the canonical enhancer box (E-box). As a member of the bHLH family, it is a transcriptional repressor that influences cell proliferation and differentiation in embryogenesis. HES1 regulates its own expression via a negative feedback loop, and oscillates with approximately 2-hour periodicity.".
- HES1 entrezgene "3280".
- HES1 wikiPageID "14761897".
- HES1 wikiPageRevisionID "591639910".
- HES1 hasPhotoCollection HES1.
- HES1 subject Category:Transcription_factors.
- HES1 type Biomolecule.
- HES1 type Protein.
- HES1 type BiologicalObject.
- HES1 comment "Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.".
- HES1 label "HES1".
- HES1 sameAs m.03gx2mn.
- HES1 sameAs Q5629472.
- HES1 sameAs Q5629472.
- HES1 wasDerivedFrom HES1?oldid=591639910.
- HES1 isPrimaryTopicOf HES1.